eF-site ID 4n76-B PDB Code 4n76 Chain B click to enlarge Title Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+ Classification NUCLEAR PROTEIN/DNA Compound Argonaute Source Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4N76) Sequence B:  HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYP LLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTY AYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEG VWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLE VDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLR LEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKP IPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIG RRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGF YRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRL HTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDR NRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKA GLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDG GHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLP SRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGG GRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLK LVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHL ADRLVKEVGRLGIRHLKEVDREKLFFV Description Functional site 1) chain B residue 433 type sequence Q description BINDING SITE FOR RESIDUE MN B 701 source : AC1 2) chain B residue 457 type sequence K description BINDING SITE FOR RESIDUE MN B 701 source : AC1 3) chain B residue 685 type sequence V description BINDING SITE FOR RESIDUE MN B 701 source : AC1 4) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE MN B 702 source : AC2 5) chain B residue 479 type sequence A description BINDING SITE FOR RESIDUE MN B 702 source : AC2 6) chain B residue 512 type sequence E description BINDING SITE FOR RESIDUE MN B 702 source : AC2 7) chain B residue 546 type sequence D description BINDING SITE FOR RESIDUE MN B 702 source : AC2 8) chain B residue 478 type sequence D description BINDING SITE FOR RESIDUE MN B 703 source : AC3 9) chain B residue 660 type sequence D description BINDING SITE FOR RESIDUE MN B 703 source : AC3 10) chain B residue 195 type sequence N description BINDING SITE FOR RESIDUE DT B 704 source : AC4 11) chain B residue 197 type sequence Y description BINDING SITE FOR RESIDUE DT B 704 source : AC4 12) chain B residue 218 type sequence P description BINDING SITE FOR RESIDUE DT B 704 source : AC4 13) chain B residue 226 type sequence Y description BINDING SITE FOR RESIDUE DT B 704 source : AC4 14) chain B residue 227 type sequence H description BINDING SITE FOR RESIDUE DT B 704 source : AC4 15) chain B residue 232 type sequence R description BINDING SITE FOR RESIDUE DT B 704 source : AC4 16) chain B residue 255 type sequence P description BINDING SITE FOR RESIDUE DT B 704 source : AC4 17) chain B residue 256 type sequence H description BINDING SITE FOR RESIDUE DT B 704 source : AC4 18) chain B residue 478 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 19) chain B residue 546 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 20) chain B residue 660 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI1 21) chain B residue 512 type ACT_SITE sequence E description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 478 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 546 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 660 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI4 25) chain B residue 685 type BINDING sequence V description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76 source Swiss-Prot : SWS_FT_FI5

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