eF-site ID 4n76-B
PDB Code 4n76
Chain B

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Title Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+
Classification NUCLEAR PROTEIN/DNA
Compound Argonaute
Source Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4N76)
Sequence B:  HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYP
LLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTY
AYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEG
VWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLE
VDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLR
LEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKP
IPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIG
RRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGF
YRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRL
HTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDR
NRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKA
GLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDG
GHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLP
SRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGG
GRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLK
LVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHL
ADRLVKEVGRLGIRHLKEVDREKLFFV
Description


Functional site

1) chain B
residue 433
type
sequence Q
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

2) chain B
residue 457
type
sequence K
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

3) chain B
residue 685
type
sequence V
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

4) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

5) chain B
residue 479
type
sequence A
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

6) chain B
residue 512
type
sequence E
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

7) chain B
residue 546
type
sequence D
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

8) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MN B 703
source : AC3

9) chain B
residue 660
type
sequence D
description BINDING SITE FOR RESIDUE MN B 703
source : AC3

10) chain B
residue 195
type
sequence N
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

11) chain B
residue 197
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

12) chain B
residue 218
type
sequence P
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

13) chain B
residue 226
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

14) chain B
residue 227
type
sequence H
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

15) chain B
residue 232
type
sequence R
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

16) chain B
residue 255
type
sequence P
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

17) chain B
residue 256
type
sequence H
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

18) chain B
residue 478
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

19) chain B
residue 546
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

20) chain B
residue 660
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

21) chain B
residue 512
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI2

22) chain B
residue 478
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI3

23) chain B
residue 546
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

24) chain B
residue 660
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

25) chain B
residue 685
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI5


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