eF-site ID 4n76-ABCDEF
PDB Code 4n76
Chain A, B, C, D, E, F

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Title Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+
Classification NUCLEAR PROTEIN/DNA
Compound Argonaute
Source Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4N76)
Sequence A:  HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEV
YPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARM
GQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLR
RLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGA
FLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLS
LLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWE
ERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGR
RAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRA
LLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQ
AVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEER
HRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRES
FRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLE
ETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALARE
GIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLL
TVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPA
SGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFF
V
B:  HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGRVYP
LLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARQTY
AYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLRRLEG
VWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGAFLLE
VDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRTWELLR
LEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVARKP
IPHLTGLLVPVLTLEDLSLALSLPWEERRRRTREIASWIG
RRLGLGTPEAVRAQAYRLSIPKLMGRRAVSKPADALRVGF
YRAQETALALLRLDGAQGWPEFLRRALLRAFGASGASLRL
HTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDR
NRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAKA
GLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDG
GHLLWTLPEAQAGERIPQEVVWDLLEETLWAFRRKAGRLP
SRVLLLRDGRVPQDEFALALEALAREGIAYDLVSVRKSGG
GRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLK
LVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHL
ADRLVKEVGRLGIRHLKEVDREKLFFV
C:  TGAGGTAGTA
D:  TACTACCTCG
E:  TGAGGTAGTAG
F:  TACTACCTCG
Description


Functional site

1) chain B
residue 433
type
sequence Q
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

2) chain B
residue 457
type
sequence K
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

3) chain B
residue 685
type
sequence V
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

4) chain E
residue 1
type
sequence T
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

5) chain E
residue 3
type
sequence A
description BINDING SITE FOR RESIDUE MN B 701
source : AC1

6) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

7) chain B
residue 479
type
sequence A
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

8) chain B
residue 512
type
sequence E
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

9) chain B
residue 546
type
sequence D
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

10) chain F
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MN B 702
source : AC2

11) chain B
residue 478
type
sequence D
description BINDING SITE FOR RESIDUE MN B 703
source : AC3

12) chain B
residue 660
type
sequence D
description BINDING SITE FOR RESIDUE MN B 703
source : AC3

13) chain F
residue 10
type
sequence T
description BINDING SITE FOR RESIDUE MN B 703
source : AC3

14) chain A
residue 37
type
sequence P
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

15) chain A
residue 39
type
sequence R
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

16) chain A
residue 42
type
sequence V
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

17) chain B
residue 195
type
sequence N
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

18) chain B
residue 197
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

19) chain B
residue 218
type
sequence P
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

20) chain B
residue 226
type
sequence Y
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

21) chain B
residue 227
type
sequence H
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

22) chain B
residue 232
type
sequence R
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

23) chain B
residue 255
type
sequence P
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

24) chain B
residue 256
type
sequence H
description BINDING SITE FOR RESIDUE DT B 704
source : AC4

25) chain A
residue 457
type
sequence K
description BINDING SITE FOR RESIDUE MN C 101
source : AC5

26) chain A
residue 685
type
sequence V
description BINDING SITE FOR RESIDUE MN C 101
source : AC5

27) chain C
residue 1
type
sequence T
description BINDING SITE FOR RESIDUE MN C 101
source : AC5

28) chain C
residue 3
type
sequence A
description BINDING SITE FOR RESIDUE MN C 101
source : AC5

29) chain A
residue 478
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

30) chain A
residue 546
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

31) chain A
residue 660
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

32) chain B
residue 478
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

33) chain B
residue 546
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

34) chain B
residue 660
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 512
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI2

36) chain B
residue 512
type ACT_SITE
sequence E
description ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
source Swiss-Prot : SWS_FT_FI2

37) chain A
residue 478
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI3

38) chain B
residue 478
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI3

39) chain A
residue 546
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

40) chain A
residue 660
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

41) chain B
residue 546
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

42) chain B
residue 660
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI4

43) chain A
residue 685
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI5

44) chain B
residue 685
type BINDING
sequence V
description BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
source Swiss-Prot : SWS_FT_FI5


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