|
|
eF-site ID
|
4n76-A |
|
PDB Code
|
4n76 |
|
Chain
|
A |
|
click to enlarge
|
|
|
Title
|
Structure of Thermus thermophilus Argonaute bound to guide DNA and cleaved target DNA with Mn2+ |
|
Classification
|
NUCLEAR PROTEIN/DNA |
|
Compound
|
Argonaute |
|
Source
|
Thermus thermophilus (strain HB27 / ATCC BAA-163 / DSM 7039) (4N76) |
|
|
Sequence
|
A: |
HLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEV
YPLLAQVARRAGGVTVRMGDGLASWSPPEVLVLEGTLARM
GQTYAYRLYPKGRRPLDPKDPGERSVLSALARRLLQERLR
RLEGVWVEGLAVYRREHARGPGWRVLGGAVLDLWVSDSGA
FLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNALPGGLS
LLDYHASKGRLQGREGGHLTGLLVPVLTLEDSLALSLPWE
ERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKLMGR
RAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRA
LLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQ
AVLVLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEER
HRWENALLGLLAKAGLQVVALSGAYPAELAVGFDAGGRES
FRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWDLLE
ETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALALEALARE
GIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLL
TVHRDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPA
SGFAFPRLPAPLHLADRLVKEVGRLGIRHLKEVDREKLFF
V
|
|
|
Description
|
|
Functional site
|
|
|
1)
|
chain |
A |
| residue |
37 |
| type |
|
| sequence |
P
|
| description |
BINDING SITE FOR RESIDUE DT B 704
|
| source |
: AC4
|
|
|
2)
|
chain |
A |
| residue |
39 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE DT B 704
|
| source |
: AC4
|
|
|
3)
|
chain |
A |
| residue |
42 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE DT B 704
|
| source |
: AC4
|
|
|
4)
|
chain |
A |
| residue |
457 |
| type |
|
| sequence |
K
|
| description |
BINDING SITE FOR RESIDUE MN C 101
|
| source |
: AC5
|
|
|
5)
|
chain |
A |
| residue |
685 |
| type |
|
| sequence |
V
|
| description |
BINDING SITE FOR RESIDUE MN C 101
|
| source |
: AC5
|
|
|
6)
|
chain |
A |
| residue |
478 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
A |
| residue |
546 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
A |
| residue |
660 |
| type |
ACT_SITE |
| sequence |
D
|
| description |
ACT_SITE => ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
A |
| residue |
512 |
| type |
ACT_SITE |
| sequence |
E
|
| description |
ACT_SITE => ECO:0000305|PubMed:24374628, ECO:0000305|PubMed:28911094
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
A |
| residue |
478 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
A |
| residue |
546 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
12)
|
chain |
A |
| residue |
660 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
13)
|
chain |
A |
| residue |
685 |
| type |
BINDING |
| sequence |
V
|
| description |
BINDING => ECO:0000269|PubMed:24374628, ECO:0000305|PubMed:18754009, ECO:0000305|PubMed:19092929, ECO:0000305|PubMed:19812667, ECO:0000305|PubMed:28911094, ECO:0007744|PDB:4KPY, ECO:0007744|PDB:4N76
|
| source |
Swiss-Prot : SWS_FT_FI5
|
|
|
|