eF-site ID 4n49-A
PDB Code 4n49
Chain A

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Title Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with m7GpppG and SAM
Classification TRANSFERASE
Compound Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1
Source Homo sapiens (Human) (MTR1_HUMAN)
Sequence A:  VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR
KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTR
ANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGK
PLVKDREAELLYFADVCAGPGGFSEYVLWRKKWHAKGFGM
TLKGPNDFKLEDFYSFEPYYGEGGIDGDGDITRPENISAF
RNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLL
CQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFE
RVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNI
KLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCS
LQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQA
RV
Description


Functional site

1) chain A
residue 234
type
sequence N
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

2) chain A
residue 236
type
sequence A
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

3) chain A
residue 277
type
sequence C
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

4) chain A
residue 278
type
sequence A
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

5) chain A
residue 279
type
sequence G
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

6) chain A
residue 280
type
sequence P
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

7) chain A
residue 281
type
sequence G
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

8) chain A
residue 282
type
sequence G
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

9) chain A
residue 283
type
sequence F
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

10) chain A
residue 301
type
sequence T
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

11) chain A
residue 302
type
sequence L
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

12) chain A
residue 306
type
sequence N
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

13) chain A
residue 334
type
sequence G
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

14) chain A
residue 335
type
sequence D
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

15) chain A
residue 336
type
sequence I
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

16) chain A
residue 364
type
sequence D
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

17) chain A
residue 366
type
sequence G
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

18) chain A
residue 383
type
sequence L
description BINDING SITE FOR RESIDUE SAM A 601
source : AC1

19) chain A
residue 203
type
sequence K
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

20) chain A
residue 204
type
sequence S
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

21) chain A
residue 206
type
sequence F
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

22) chain A
residue 207
type
sequence D
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

23) chain A
residue 214
type
sequence M
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

24) chain A
residue 218
type
sequence R
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

25) chain A
residue 373
type
sequence E
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

26) chain A
residue 374
type
sequence N
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

27) chain A
residue 438
type
sequence A
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

28) chain A
residue 439
type
sequence N
description BINDING SITE FOR RESIDUE MGT A 602
source : AC2

29) chain A
residue 235
type
sequence R
description BINDING SITE FOR RESIDUE NA A 603
source : AC3

30) chain A
residue 239
type
sequence K
description BINDING SITE FOR RESIDUE NA A 603
source : AC3

31) chain A
residue 436
type
sequence R
description BINDING SITE FOR RESIDUE NA A 603
source : AC3

32) chain A
residue 439
type
sequence N
description BINDING SITE FOR RESIDUE NA A 603
source : AC3

33) chain A
residue 441
type
sequence E
description BINDING SITE FOR RESIDUE NA A 603
source : AC3

34) chain A
residue 239
type ACT_SITE
sequence K
description ACT_SITE => ECO:0000305|PubMed:21310715
source Swiss-Prot : SWS_FT_FI1

35) chain A
residue 364
type ACT_SITE
sequence D
description ACT_SITE => ECO:0000305|PubMed:21310715
source Swiss-Prot : SWS_FT_FI1

36) chain A
residue 404
type ACT_SITE
sequence K
description Proton acceptor => ECO:0000305|PubMed:21310715
source Swiss-Prot : SWS_FT_FI2

37) chain A
residue 203
type BINDING
sequence K
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

38) chain A
residue 218
type BINDING
sequence R
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

39) chain A
residue 234
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

40) chain A
residue 277
type BINDING
sequence C
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

41) chain A
residue 335
type BINDING
sequence D
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

42) chain A
residue 374
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3

43) chain A
residue 439
type BINDING
sequence N
description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49
source Swiss-Prot : SWS_FT_FI3


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