eF-site ID 4n48-B PDB Code 4n48 Chain B click to enlarge Title Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment Classification TRANSFERASE/RNA Compound Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Source Homo sapiens (Human) (4N48) Sequence B:  VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTR ANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGK PLVKDRELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTL KGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENI SAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQ LLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYC CFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFA VNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNES HCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIP DQARV Description Functional site 1) chain B residue 234 type sequence N description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 2) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 3) chain B residue 277 type sequence C description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 4) chain B residue 278 type sequence A description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 5) chain B residue 279 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 6) chain B residue 280 type sequence P description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 7) chain B residue 281 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 8) chain B residue 282 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 9) chain B residue 283 type sequence F description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 10) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 11) chain B residue 302 type sequence L description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 12) chain B residue 306 type sequence N description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 13) chain B residue 334 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 14) chain B residue 335 type sequence D description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 15) chain B residue 336 type sequence I description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 16) chain B residue 337 type sequence T description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 17) chain B residue 364 type sequence D description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 18) chain B residue 365 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 19) chain B residue 366 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 20) chain B residue 203 type sequence K description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 21) chain B residue 204 type sequence S description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 22) chain B residue 206 type sequence F description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 23) chain B residue 207 type sequence D description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 24) chain B residue 214 type sequence M description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 25) chain B residue 218 type sequence R description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 26) chain B residue 373 type sequence E description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 27) chain B residue 374 type sequence N description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 28) chain B residue 376 type sequence Q description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 29) chain B residue 438 type sequence A description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 30) chain B residue 439 type sequence N description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 31) chain B residue 239 type ACT_SITE sequence K description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 32) chain B residue 364 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 33) chain B residue 404 type ACT_SITE sequence K description Proton acceptor => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI2 34) chain B residue 234 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 35) chain B residue 277 type BINDING sequence C description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 36) chain B residue 335 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 374 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 38) chain B residue 439 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 39) chain B residue 203 type BINDING sequence K description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 40) chain B residue 218 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3

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