eF-site ID 4n48-AB PDB Code 4n48 Chain A, B click to enlarge Title Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment Classification TRANSFERASE/RNA Compound Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Source Homo sapiens (Human) (4N48) Sequence A:  VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTR ANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGK PLVKDRELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTL KGPNDFKLEDFSELFEPYYGEGGIDGDGDITRPENISAFR NFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLC QFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFER VCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIK LNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSL QIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQAR V B:  VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTR ANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGK PLVKDRELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTL KGPNDFKLEDFYSASSELFEPYYGEGGIDGDGDITRPENI SAFRNFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQ LLLCQFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYC CFERVCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFA VNIKLNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNES HCSLQIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIP DQARV Description Functional site 1) chain A residue 234 type sequence N description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 2) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 3) chain A residue 277 type sequence C description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 4) chain A residue 278 type sequence A description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 5) chain A residue 279 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 6) chain A residue 280 type sequence P description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 7) chain A residue 281 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 8) chain A residue 282 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 9) chain A residue 283 type sequence F description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 10) chain A residue 302 type sequence L description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 11) chain A residue 306 type sequence N description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 12) chain A residue 334 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 13) chain A residue 335 type sequence D description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 14) chain A residue 336 type sequence I description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 15) chain A residue 337 type sequence T description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 16) chain A residue 364 type sequence D description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 17) chain A residue 365 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 18) chain A residue 366 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 19) chain B residue 234 type sequence N description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 20) chain B residue 236 type sequence A description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 21) chain B residue 277 type sequence C description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 22) chain B residue 278 type sequence A description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 23) chain B residue 279 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 24) chain B residue 280 type sequence P description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 25) chain B residue 281 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 26) chain B residue 282 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 27) chain B residue 283 type sequence F description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 28) chain B residue 301 type sequence T description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 29) chain B residue 302 type sequence L description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 30) chain B residue 306 type sequence N description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 31) chain B residue 334 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 32) chain B residue 335 type sequence D description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 33) chain B residue 336 type sequence I description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 34) chain B residue 337 type sequence T description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 35) chain B residue 364 type sequence D description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 36) chain B residue 365 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 37) chain B residue 366 type sequence G description BINDING SITE FOR RESIDUE SAM B 601 source : AC2 38) chain A residue 203 type sequence K description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 39) chain A residue 204 type sequence S description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 40) chain A residue 206 type sequence F description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 41) chain A residue 207 type sequence D description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 42) chain A residue 214 type sequence M description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 43) chain A residue 218 type sequence R description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 44) chain A residue 373 type sequence E description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 45) chain A residue 374 type sequence N description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 46) chain A residue 376 type sequence Q description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 47) chain A residue 438 type sequence A description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 48) chain A residue 439 type sequence N description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 49) chain A residue 440 type sequence S description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 50) chain B residue 203 type sequence K description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 51) chain B residue 204 type sequence S description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 52) chain B residue 206 type sequence F description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 53) chain B residue 207 type sequence D description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 54) chain B residue 214 type sequence M description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 55) chain B residue 218 type sequence R description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 56) chain B residue 373 type sequence E description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 57) chain B residue 374 type sequence N description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 58) chain B residue 376 type sequence Q description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 59) chain B residue 438 type sequence A description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 60) chain B residue 439 type sequence N description BINDING SITE FOR RESIDUE MGT G 101 source : AC4 61) chain A residue 239 type ACT_SITE sequence K description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 364 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 63) chain B residue 239 type ACT_SITE sequence K description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 64) chain B residue 364 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 65) chain A residue 203 type BINDING sequence K description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 66) chain B residue 234 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 67) chain B residue 277 type BINDING sequence C description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 68) chain B residue 335 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 69) chain B residue 374 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 70) chain B residue 439 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 71) chain A residue 218 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 72) chain A residue 234 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 73) chain A residue 277 type BINDING sequence C description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 74) chain A residue 335 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 75) chain A residue 374 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 76) chain A residue 439 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 77) chain B residue 203 type BINDING sequence K description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 78) chain B residue 218 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 79) chain A residue 404 type ACT_SITE sequence K description Proton acceptor => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI2 80) chain B residue 404 type ACT_SITE sequence K description Proton acceptor => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI2

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