eF-site ID 4n48-A PDB Code 4n48 Chain A click to enlarge Title Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Protein in complex with capped RNA fragment Classification TRANSFERASE/RNA Compound Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 1 Source Homo sapiens (Human) (4N48) Sequence A:  VDWRDEPEPSACEQVSWFPECTTEIPDTQEMSDWMVVGKR KMIIEDETEFCGEELLHSVLQCKSVFDVLDGEEMRRARTR ANPYEMIRGVFFLNRAAMKMANMDFVFDRMFTNPRDSYGK PLVKDRELLYFADVCAGPGGFSEYVLWRKKWHAKGFGMTL KGPNDFKLEDFSELFEPYYGEGGIDGDGDITRPENISAFR NFVLDNTDRKGVHFLMADGGFSVEGQENLQEILSKQLLLC QFLMALSIVRTGGHFICKTFDLFTPFSVGLVYLLYCCFER VCLFKPITSRPANSERYVVCKGLKVGIDDVRDYLFAVNIK LNQLRNTDSDVNLVVPLEVIKGDHEFTDYMIRSNESHCSL QIKALAKIHAFVQDTTLSEPRQAEIRKECLRLWGIPDQAR V Description Functional site 1) chain A residue 234 type sequence N description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 2) chain A residue 236 type sequence A description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 3) chain A residue 277 type sequence C description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 4) chain A residue 278 type sequence A description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 5) chain A residue 279 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 6) chain A residue 280 type sequence P description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 7) chain A residue 281 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 8) chain A residue 282 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 9) chain A residue 283 type sequence F description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 10) chain A residue 302 type sequence L description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 11) chain A residue 306 type sequence N description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 12) chain A residue 334 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 13) chain A residue 335 type sequence D description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 14) chain A residue 336 type sequence I description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 15) chain A residue 337 type sequence T description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 16) chain A residue 364 type sequence D description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 17) chain A residue 365 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 18) chain A residue 366 type sequence G description BINDING SITE FOR RESIDUE SAM A 601 source : AC1 19) chain A residue 203 type sequence K description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 20) chain A residue 204 type sequence S description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 21) chain A residue 206 type sequence F description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 22) chain A residue 207 type sequence D description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 23) chain A residue 214 type sequence M description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 24) chain A residue 218 type sequence R description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 25) chain A residue 373 type sequence E description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 26) chain A residue 374 type sequence N description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 27) chain A residue 376 type sequence Q description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 28) chain A residue 438 type sequence A description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 29) chain A residue 439 type sequence N description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 30) chain A residue 440 type sequence S description BINDING SITE FOR RESIDUE MGT D 101 source : AC3 31) chain A residue 239 type ACT_SITE sequence K description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 32) chain A residue 364 type ACT_SITE sequence D description ACT_SITE => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 404 type ACT_SITE sequence K description Proton acceptor => ECO:0000305|PubMed:21310715 source Swiss-Prot : SWS_FT_FI2 34) chain A residue 203 type BINDING sequence K description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 35) chain A residue 218 type BINDING sequence R description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 234 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 37) chain A residue 277 type BINDING sequence C description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 38) chain A residue 335 type BINDING sequence D description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 39) chain A residue 374 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3 40) chain A residue 439 type BINDING sequence N description BINDING => ECO:0000269|PubMed:24402442, ECO:0007744|PDB:4N48, ECO:0007744|PDB:4N49 source Swiss-Prot : SWS_FT_FI3

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