eF-site ID 4n44-AB PDB Code 4n44 Chain A, B click to enlarge Title Crystal structure of oxidized form of thiolase from Clostridium acetobutylicum Classification TRANSFERASE Compound Acetyl-CoA acetyltransferase Source (F0K5D8_CLOAE) Sequence A:  MKEVVIASAVRTAIGSYGKSLKDVPAVDLGATAIKEAVKK AGIKPEDVNEVILGNVLQAGLGQNPARQASFKAGLPVEIP AMTINKVCGSGLRTVSLAAQIIKAGDADVIIAGGMENMSR APYLANNARWGYRMGNAKFVDEMITDGLWDAFNDYHMGIT AENIAERWNISREEQDEFALASQKKAEEAIKSGQFKDEIV PVVIKGRKGETVVDTDEHPRFGSTIEGLAKLKPAFKKDGT VTAGNASGLNDCAAVLVIMSAEKAKELGVKPLAKIVSYGS AGVDPAIMGYGPFYATKAAIEKAGWTVDELDLIESNEAFA AQSLAVAKDLKFDMNKVNVNGGAIALGHPIGASGARILVT LVHAMQKRDAKKGLATLCIGGGQGTAILLEKC B:  MKEVVIASAVRTAIGSYGKSLKDVPAVDLGATAIKEAVKK AGIKPEDVNEVILGNVLQAGLGQNPARQASFKAGLPVEIP AMTINKVCGSGLRTVSLAAQIIKAGDADVIIAGGMENMSR APYLANNARWGYRMGNAKFVDEMITDGLWDAFNDYHMGIT AENIAERWNISREEQDEFALASQKKAEEAIKSGQFKDEIV PVVIKGRKGETVVDTDEHPRFGSTIEGLAKLKPAFKKDGT VTAGNASGLNDCAAVLVIMSAEKAKELGVKPLAKIVSYGS AGVDPAIMGYGPFYATKAAIEKAGWTVDELDLIESNEAFA AQSLAVAKDLKFDMNKVNVNGGAIALGHPIGASGARILVT LVHAMQKRDAKKGLATLCIGGGQGTAILLEKC Description Functional site 1) chain A residue 96 type sequence S description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 2) chain A residue 279 type sequence G description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 3) chain A residue 280 type sequence S description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 4) chain A residue 385 type sequence T description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 5) chain A residue 386 type sequence A description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 6) chain A residue 387 type sequence I description BINDING SITE FOR RESIDUE ACT A 401 source : AC1 7) chain A residue 148 type sequence L description BINDING SITE FOR RESIDUE ACT A 402 source : AC2 8) chain A residue 247 type sequence S description BINDING SITE FOR RESIDUE ACT A 402 source : AC2 9) chain A residue 248 type sequence G description BINDING SITE FOR RESIDUE ACT A 402 source : AC2 10) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 11) chain B residue 279 type sequence G description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 12) chain B residue 280 type sequence S description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 13) chain B residue 385 type sequence T description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 14) chain B residue 386 type sequence A description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 15) chain B residue 387 type sequence I description BINDING SITE FOR RESIDUE ACT B 401 source : AC3 16) chain B residue 148 type sequence L description BINDING SITE FOR RESIDUE ACT B 402 source : AC4 17) chain B residue 247 type sequence S description BINDING SITE FOR RESIDUE ACT B 402 source : AC4 18) chain B residue 248 type sequence G description BINDING SITE FOR RESIDUE ACT B 402 source : AC4 19) chain B residue 318 type sequence A description BINDING SITE FOR RESIDUE ACT B 402 source : AC4 20) chain B residue 348 type sequence H description BINDING SITE FOR RESIDUE ACT B 402 source : AC4 21) chain B residue 216 type sequence D description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 22) chain B residue 217 type sequence E description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 23) chain B residue 219 type sequence P description BINDING SITE FOR RESIDUE GOL B 403 source : AC5 24) chain B residue 32 type sequence T description BINDING SITE FOR RESIDUE GOL B 404 source : AC6 25) chain B residue 72 type sequence K description BINDING SITE FOR RESIDUE GOL B 404 source : AC6 26) chain A residue 84-102 type prosite sequence INKVCGSGLRTVSLAAQII description THIOLASE_1 Thiolases acyl-enzyme intermediate signature. INKvCGSGLrTVslaaqiI source prosite : PS00098 27) chain A residue 373-386 type prosite sequence GLATLCIGGGQGTA description THIOLASE_3 Thiolases active site. GLATLCIGgGqGtA source prosite : PS00099 28) chain A residue 338-354 type prosite sequence NVNGGAIALGHPIGASG description THIOLASE_2 Thiolases signature 2. NvnGGaIAlGHPiGaSG source prosite : PS00737

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