eF-site ID 4msm-ABCD PDB Code 4msm Chain A, B, C, D click to enlarge Title Crystal structure of Schizosaccharomyces pombe AMSH-like protease sst2 E286A mutant bound to ubiquitin Classification HYDROLASE/PROTEIN BINDING Compound AMSH-like protease sst2 Source (UBC_HUMAN) Sequence A:  KIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLATC GILCGKLRQNAFFITHLVIPLQEATSDTCGTTDEASLFEF QDKHNLLTLGWIHTHPTQTCFMSSVDLHTHCSYQLMLPEA IAIVMAPSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPHEG KVYTMVAQPGHVREINSKLQVVDLRV B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG C:  FKIHAYTEGGKPLRTIYLPKLLKKVFLDVVKPNTKKNLAT CGILCGKLRQNAFFITHLVIPLQEATSDTCGTTDEASLFE FQDKHNLLTLGWIHTHPTQTCFMSSVDLHTHCSYQLMLPE AIAIVMAPSKNTSGIFRLLDPEGLQTIVKCRKPGLFHPHE GKVYTMVAQPGHVREINSKLQVVDLR D:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 341 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 2) chain A residue 343 type sequence H description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 3) chain A residue 354 type sequence D description BINDING SITE FOR RESIDUE ZN A 501 source : AC1 4) chain A residue 356 type sequence H description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 5) chain A residue 397 type sequence C description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 6) chain A residue 404 type sequence H description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 7) chain A residue 406 type sequence H description BINDING SITE FOR RESIDUE ZN A 502 source : AC2 8) chain A residue 261 type sequence R description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 9) chain B residue 9 type sequence T description BINDING SITE FOR RESIDUE EDO A 503 source : AC3 10) chain A residue 356 type sequence H description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 11) chain A residue 359 type sequence C description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 12) chain A residue 360 type sequence S description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 13) chain B residue 37 type sequence P description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 14) chain B residue 40 type sequence Q description BINDING SITE FOR RESIDUE EDO A 504 source : AC4 15) chain A residue 409 type sequence K description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 16) chain A residue 412 type sequence T description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 17) chain A residue 413 type sequence M description BINDING SITE FOR RESIDUE PO4 A 505 source : AC5 18) chain B residue 7 type sequence T description BINDING SITE FOR RESIDUE EDO B 101 source : AC6 19) chain B residue 8 type sequence L description BINDING SITE FOR RESIDUE EDO B 101 source : AC6 20) chain B residue 69 type sequence L description BINDING SITE FOR RESIDUE EDO B 101 source : AC6 21) chain B residue 70 type sequence V description BINDING SITE FOR RESIDUE EDO B 101 source : AC6 22) chain B residue 71 type sequence L description BINDING SITE FOR RESIDUE EDO B 101 source : AC6 23) chain B residue 54 type sequence R description BINDING SITE FOR RESIDUE EDO B 102 source : AC7 24) chain C residue 409 type sequence K description BINDING SITE FOR RESIDUE EDO B 102 source : AC7 25) chain C residue 411 type sequence Y description BINDING SITE FOR RESIDUE EDO B 102 source : AC7 26) chain C residue 341 type sequence H description BINDING SITE FOR RESIDUE ZN C 501 source : AC8 27) chain C residue 343 type sequence H description BINDING SITE FOR RESIDUE ZN C 501 source : AC8 28) chain C residue 354 type sequence D description BINDING SITE FOR RESIDUE ZN C 501 source : AC8 29) chain C residue 356 type sequence H description BINDING SITE FOR RESIDUE ZN C 502 source : AC9 30) chain C residue 397 type sequence C description BINDING SITE FOR RESIDUE ZN C 502 source : AC9 31) chain C residue 404 type sequence H description BINDING SITE FOR RESIDUE ZN C 502 source : AC9 32) chain C residue 406 type sequence H description BINDING SITE FOR RESIDUE ZN C 502 source : AC9 33) chain C residue 274 type sequence L description BINDING SITE FOR RESIDUE EDO C 503 source : BC1 34) chain C residue 375 type sequence P description BINDING SITE FOR RESIDUE EDO C 503 source : BC1 35) chain C residue 294 type sequence K description BINDING SITE FOR RESIDUE EDO C 504 source : BC2 36) chain C residue 258 type sequence K description BINDING SITE FOR RESIDUE EDO C 505 source : BC3 37) chain C residue 362 type sequence Q description BINDING SITE FOR RESIDUE EDO C 505 source : BC3 38) chain C residue 363 type sequence L description BINDING SITE FOR RESIDUE EDO C 505 source : BC3 39) chain C residue 366 type sequence P description BINDING SITE FOR RESIDUE EDO C 505 source : BC3 40) chain C residue 387 type sequence D description BINDING SITE FOR RESIDUE EDO C 505 source : BC3 41) chain C residue 356 type sequence H description BINDING SITE FOR RESIDUE EDO C 506 source : BC4 42) chain C residue 397 type sequence C description BINDING SITE FOR RESIDUE EDO C 506 source : BC4 43) chain C residue 398 type sequence R description BINDING SITE FOR RESIDUE EDO C 506 source : BC4 44) chain C residue 399 type sequence K description BINDING SITE FOR RESIDUE EDO C 506 source : BC4 45) chain C residue 404 type sequence H description BINDING SITE FOR RESIDUE EDO C 506 source : BC4 46) chain C residue 311 type sequence E description BINDING SITE FOR RESIDUE EDO C 507 source : BC5 47) chain C residue 318 type sequence G description BINDING SITE FOR RESIDUE EDO C 507 source : BC5 48) chain C residue 319 type sequence T description BINDING SITE FOR RESIDUE EDO C 507 source : BC5 49) chain C residue 320 type sequence T description BINDING SITE FOR RESIDUE EDO C 507 source : BC5 50) chain D residue 74 type sequence R description BINDING SITE FOR RESIDUE EDO C 507 source : BC5 51) chain C residue 409 type sequence K description BINDING SITE FOR RESIDUE PO4 C 508 source : BC6 52) chain C residue 412 type sequence T description BINDING SITE FOR RESIDUE PO4 C 508 source : BC6 53) chain C residue 413 type sequence M description BINDING SITE FOR RESIDUE PO4 C 508 source : BC6 54) chain D residue 7 type sequence T description BINDING SITE FOR RESIDUE EDO D 101 source : BC7 55) chain D residue 8 type sequence L description BINDING SITE FOR RESIDUE EDO D 101 source : BC7 56) chain D residue 69 type sequence L description BINDING SITE FOR RESIDUE EDO D 101 source : BC7 57) chain D residue 70 type sequence V description BINDING SITE FOR RESIDUE EDO D 101 source : BC7 58) chain D residue 71 type sequence L description BINDING SITE FOR RESIDUE EDO D 101 source : BC7 59) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 60) chain A residue 341 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 61) chain A residue 343 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 62) chain A residue 354 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 63) chain C residue 341 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 64) chain C residue 343 type BINDING sequence H description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 65) chain C residue 354 type BINDING sequence D description BINDING => ECO:0000255|PROSITE-ProRule:PRU01182 source Swiss-Prot : SWS_FT_FI1 66) chain A residue 356 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 67) chain A residue 397 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 68) chain A residue 404 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 69) chain A residue 406 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 70) chain C residue 356 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 71) chain C residue 397 type BINDING sequence C description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 72) chain C residue 404 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 73) chain C residue 406 type BINDING sequence H description BINDING => ECO:0000250 source Swiss-Prot : SWS_FT_FI2 74) chain A residue 286 type SITE sequence A description Indirect zinc-binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 75) chain C residue 286 type SITE sequence A description Indirect zinc-binding => ECO:0000250 source Swiss-Prot : SWS_FT_FI3

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