eF-site ID 4mq9-D
PDB Code 4mq9
Chain D

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Title Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077
Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC
Compound DNA-directed RNA polymerase subunit alpha
Source ORGANISM_SCIENTIFIC: Thermus thermophilus;
Sequence D:  KKEVRKVRIALASPEKIRSWSYGEVEKPETINYRTLKPER
DGLFDERIFGPIKDYECACGKYKRQRFEGKVCERCGVEVT
KSIVRRYRMGHIELATPAAHIWFVKDVPSKIGTLLDLSAT
ELEQVLYFSKYIVLDPKGAILNGVPVEKRQLLTDEEYREL
RYGKQETYPLPPGVDALVKDGEEVVKGQELAPGVVSRLDG
VALYRFPRRVRVEYWTEPKDYRVQPHMNVVVPEGARVEAG
DKIVAAIDPEEEVIAEAEGVVHLHEPASILVVKARVYPFE
DDVEVSTGDRVAPGDVLADGGKVKSDVYGRVEVDLVRNVV
RVVESYDIDARMGAEAIQQLLKELDLEALEKELLEEMKHP
SRARRAKARKRLEVVRAFLDSGNRPEWMILEAVPVLPPDL
RPMVQVDGGRFATSDLNDLYRRLINRNNRLKKLLAQGAPE
IIIRNEKRMLQEAVDALLDNGRRGAPVTNPGSDRPLRSLT
DILSGKQGRFRQNLLGKRVDYSGRSVIVVGPQLKLHQCGL
PKRMALELFKPFLLKKMEEKGIAPNVKAARRMLERQRDIK
DEVWDALEEVIHGKVVLLNRAPTLHRLGIQAFQPVLVEGQ
SIQLHPLVCEAFNADFDGDQMAVHVPLSSFAQAEARIQML
SAHNLLSPASGEPLAKPSRDIILGLYYITQVRKEKKGAGL
EFATPEEALAAHERGEVALNAPIKVAGRETSVGRLKYVFA
NPDEALLAVAHGIVDLQDVVTVRYMGKRLETSPGRILFAR
IVAEAVEDEKVAWELIQLDVPQEKNSLKDLVYQAFLRLGM
EKTARLLDALKYYGFTFSTTSGITIGIDDAVIPEEKKQYL
EEADRKLLQIEQAYEMGFLTDRERYDQILQLWTETTEKVT
QAVFKNFEENYPFNPLYVMAQSGARGNPQQIRQLCGLRGL
MQKPSGETFEVPVRSSFREGLTVLEYFISSHGARKGGADT
ALRTADSGYLTRKLVDVTHEIVVREADCGTTNYISVPLFQ
PDEVTRSLRLRKRADIEAGLYGRVLAREVEVLGVRLEEGR
YLSMDDVHLLIKAAEAGEIQEVPVRSPLTCQTRYGVCQKC
YGYDLSMARPVSIGEAVGIVAAQSIGEPGTQLTMRTDITQ
GLPRVIELFEARRPKAKAVISEIDGVVRIEETEEKLSVFV
ESEGFSKEYKLPKEARLLVKDGDYVEAGQPLTRGAIDPHQ
LLEAKGPEAVERYLVEEIQKVYRAQGVKLHDKHIEIVVRQ
MMKYVEVTDPGDSRLLEGQVLEKWDVEALNERLIAEGKTP
VAWKPLLMGVTKSALSTKSWLSAASFQNTTHVLTEAAIAG
KKDELIGLKENVILGRLIPAGTGSDFVRFTQVVDQKTLKA
IEEAR
Description


Functional site

1) chain D
residue 58
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1601
source : AC1

2) chain D
residue 60
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1601
source : AC1

3) chain D
residue 73
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1601
source : AC1

4) chain D
residue 76
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1601
source : AC1

5) chain D
residue 1112
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1602
source : AC2

6) chain D
residue 1194
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1602
source : AC2

7) chain D
residue 1201
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1602
source : AC2

8) chain D
residue 1204
type
sequence C
description BINDING SITE FOR RESIDUE ZN D 1602
source : AC2

9) chain D
residue 739
type
sequence D
description BINDING SITE FOR RESIDUE MG D 1603
source : AC3

10) chain D
residue 741
type
sequence D
description BINDING SITE FOR RESIDUE MG D 1603
source : AC3

11) chain D
residue 743
type
sequence D
description BINDING SITE FOR RESIDUE MG D 1603
source : AC3

12) chain D
residue 1088
type
sequence T
description BINDING SITE FOR CHAIN I OF GE23077
source : AC4

13) chain D
residue 58
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

14) chain D
residue 1201
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

15) chain D
residue 1204
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

16) chain D
residue 60
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

17) chain D
residue 73
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

18) chain D
residue 76
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

19) chain D
residue 739
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

20) chain D
residue 741
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

21) chain D
residue 743
type BINDING
sequence D
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

22) chain D
residue 1112
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1

23) chain D
residue 1194
type BINDING
sequence C
description BINDING => ECO:0000255|HAMAP-Rule:MF_01322
source Swiss-Prot : SWS_FT_FI1


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