eF-site ID 4mq9-C PDB Code 4mq9 Chain C click to enlarge Title Crystal structure of Thermus thermophilus RNA polymerase holoenzyme in complex with GE23077 Classification TRANSCRIPTION, TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source ORGANISM_SCIENTIFIC: Thermus thermophilus; Sequence C:  MEIKRFGRIREVIPLPPLTEIQVESYRRALQADVPPEKRE NVGIQAAFRETFPILDFLEYRLGEPPFPQDECREKDLTYQ APLYARLQLIHKDTGLIKEDEVFLGHIPLMTEDGSFIING ADRVIVSQIHRSPGVYFTPDPARPGRYIASIIPLPKRGPW IDLEVEPNGVVSMKVNKRKFPLVLLLRVLGYDQETLAREL GAYGELVQGLMDESVFAMRPEEALIRLFTLLRPGDPPKRD KAVAYVYGLIADPRRYDLGEAGRYKAEEKLGIRLSGRTLA DEVFLPTLRYLFALTAGVPGHEVDDIDHLGNRRIRTVGEL MTDQFRVGLARLARGVRERMLMGSEDSLTPAKLVNSRPLE AAIREFFSRSQLSQFKDETNPLSSLRHKRRISALGPGGLT RERAGFDVRDVHRTHYGRICPVETPEGANIGLITSLAAYA RVDELGFIRTPYRRVVGGVVTDEVVYMTATEEDRYTIAQA NTPLEGNRIAAERVVARRKGEPVIVSPEEVEFMDVSPKQV FSVNTNLIPFLEHDDANRALMGSNMQTQAVPLIRAQAPVV MTGLEERVVRDSLAALYAEEDGEVAKVDGNRIVVRYEDGR LVEYPLRRFYRSNQGTALDQRPRVVVGQRVRKGDLLADGP ASENGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDF YTSIHIERYEIEARDTKLGPERITRDIPHLSEAALRDLDE EGVVRIGAEVKPGDILVGRTSFKGESEPTPEERLLRSIFG EKARDVKDTSLRVPPGEGGIVVRTVRLRRGDPGVELKPGV REVVRVYVAQKRKLQVGDKLANRHGNKGVVAKILPVEDMP HLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQ RYISPIFDGAKEPEIKELLAQAFEVYFGKRKGEGFGVDKR EVEVLRRAEKLGLVTPGKTPEEQLKELFLQGKVVLYDGRT GEPIEGPIVVGQMFIMKLYHMVEDKMHARSTGPYSLITQQ PLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEMLTLKSDD IEGRNAAYEAIIKGEDVPEPSVPESFRVLVKELQALALDV QTLDEKDNPVDIFEGLASKR Description Functional site 1) chain C residue 444 type sequence P description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 2) chain C residue 445 type sequence E description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 3) chain C residue 446 type sequence G description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 4) chain C residue 448 type sequence N description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 5) chain C residue 557 type sequence R description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 6) chain C residue 560 type sequence M description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 7) chain C residue 563 type sequence N description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 8) chain C residue 567 type sequence Q description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 9) chain C residue 838 type sequence K description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 10) chain C residue 846 type sequence K description BINDING SITE FOR CHAIN I OF GE23077 source : AC4 11) chain C residue 836-848 type prosite sequence GDKLANRHGNKGV description RNA_POL_BETA RNA polymerases beta chain signature. GdKLANrHGNKGV source prosite : PS01166

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