eF-site ID 4mnq-ABCDE PDB Code 4mnq Chain A, B, C, D, E click to enlarge Title TCR-peptide specificity overrides affinity enhancing TCR-MHC interactions Classification IMMUNE SYSTEM Compound HLA class I histocompatibility antigen, A-2 alpha chain Source Homo sapiens (Human) (TRBC1_HUMAN) Sequence A:  GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDA ASQRMEPRAPWIEQEGPEYWDGETRKVKAHSQTHRVDLGT LRGYYNQSEAGSHTVQRMYGCDVGSDWRFLRGYHQYAYDG KDYIALKEDLRSWTAADMAAQTTKHKWEAAHVAEQLRAYL EGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEAT LRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGT FQKWAAVVVPSGQEQRYTCHVQHEGLPKPLTLRWEP B:  MIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDL LKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYA CRVNHVTLSQPKIVKWDRDM C:  ILAKFLHWL D:  IQVEQSPPDLILQEGANSTLRCNFSDSVNNLWWFHQNPWG QLINLFYIPSGTKQNGRLSATTVATERYSLLYISSSQTTD SGVYFCAVDSATALPYGYIFGTGTRLKVLANIQNPDPAVY QLRDSKSSDKSVCLFTDFDSQTNVSQSKDSDVYITDKCVL DMRSMDFKSNSAVAWSNKSDFACANAFNNSIIPEDTFFPS E:  AGVTQTPKFQVLKTGQSMTLQCAQDMNHEYMSWYRQDPGM GLRLIHYSIHPEYTDQGEVPNGYNVSRSTTEDFPLRLLSA APSQTSVYFCASSYQGTEAFFGQGTRLTVVEDLNKVFPPE VAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGK EVHSGVCTDPQPLKEQPALNDSRYALSSRLRVSATFWQDP RNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRAD Description (1)  HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, Telomerase reverse transcriptase (E.C.2.7.7.49), Uncharacterized protein, T-cell receptor, sp3.4 alpha chain, V_segment translation product, T-cell receptor beta-1 chain C region Functional site 1) chain A residue 35 type sequence R description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 2) chain A residue 40 type sequence A description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 3) chain A residue 41 type sequence A description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 4) chain A residue 42 type sequence S description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 5) chain A residue 46 type sequence E description BINDING SITE FOR RESIDUE GOL A 301 source : AC1 6) chain A residue 128 type sequence E description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 7) chain A residue 129 type sequence D description BINDING SITE FOR RESIDUE EDO A 302 source : AC2 8) chain D residue 164 type sequence R description BINDING SITE FOR RESIDUE EDO E 301 source : AC3 9) chain E residue 163 type sequence V description BINDING SITE FOR RESIDUE EDO E 301 source : AC3 10) chain E residue 164 type sequence H description BINDING SITE FOR RESIDUE EDO E 301 source : AC3 11) chain E residue 165 type sequence S description BINDING SITE FOR RESIDUE EDO E 301 source : AC3 12) chain A residue 257-263 type prosite sequence YTCHVQH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290 13) chain B residue 78-84 type prosite sequence YACRVNH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCHVQH source prosite : PS00290 14) chain E residue 65 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 73 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 84 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 143 type CARBOHYD sequence T description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 146 type CARBOHYD sequence K description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 171 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI1 20) chain E residue 180 type CARBOHYD sequence L description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 21) chain A residue 159 type CARBOHYD sequence Y description N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 source Swiss-Prot : SWS_FT_FI2 22) chain B residue 19 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 23) chain B residue 41 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 24) chain B residue 48 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 25) chain B residue 58 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 26) chain B residue 91 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 27) chain B residue 94 type CARBOHYD sequence K description N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 source Swiss-Prot : SWS_FT_FI3 28) chain A residue 86 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 source Swiss-Prot : SWS_FT_FI4

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