eF-site ID 4mm3-B PDB Code 4mm3 Chain B click to enlarge Title Crystal structure of SARS-CoV papain-like protease PLpro in complex with ubiquitin aldehyde Classification SIGNALING PROTEIN/HYDROLASE Compound Ubiquitin Source Homo sapiens (Human) (R1A_CVHSA) Sequence B:  MEVKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGA DVTKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESF LGRYMSALNHTKKWKFPQVGGLTSIKWADNNCYLSSVLLA LQQLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTV GELGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTL TGVEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQES SFVMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAK ETLYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIK Description (1)  Ubiquitin, Papain-like proteinase (E.C.3.4.19.12, 3.4.22.69) Functional site 1) chain B residue 190 type sequence C description BINDING SITE FOR RESIDUE ZN B 401 source : AC1 2) chain B residue 193 type sequence C description BINDING SITE FOR RESIDUE ZN B 401 source : AC1 3) chain B residue 225 type sequence C description BINDING SITE FOR RESIDUE ZN B 401 source : AC1 4) chain B residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN B 401 source : AC1 5) chain B residue 193 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3 6) chain B residue 225 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3 7) chain B residue 227 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3 8) chain B residue 190 type BINDING sequence C description BINDING => ECO:0000255|PROSITE-ProRule:PRU00444 source Swiss-Prot : SWS_FT_FI3 9) chain B residue 190-227 type ZN_FING sequence CKHCGQKTTTLTGVEAVMYMGTLSYDNLKTGVSIPCVC description C4-type => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 source Swiss-Prot : SWS_FT_FI1 10) chain B residue 112 type ACT_SITE sequence C description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 source Swiss-Prot : SWS_FT_FI2 11) chain B residue 273 type ACT_SITE sequence H description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 source Swiss-Prot : SWS_FT_FI2 12) chain B residue 287 type ACT_SITE sequence D description For PL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00444, ECO:0000269|PubMed:16306590 source Swiss-Prot : SWS_FT_FI2

Display surface Download Links