eF-site ID 4mi5-A PDB Code 4mi5 Chain A click to enlarge Title Crystal structure of the EZH2 SET domain Classification TRANSFERASE Compound Histone-lysine N-methyltransferase EZH2 Source Homo sapiens (Human) (EZH2_HUMAN) Sequence A:  GSLQPCDHPRQPCDSSCPCVIAQNFCEKFCQCSSECQNRF PGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADVSCKN CSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEYCG EIISQDEADRRGKVYDKYMCSFLFNLNNDFVVDATRKGNK IRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGEELF FDYRYSQA Description Functional site 1) chain A residue 568 type sequence K description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 2) chain A residue 687 type sequence N description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 3) chain A residue 688 type sequence K description BINDING SITE FOR RESIDUE SO4 A 801 source : AC1 4) chain A residue 565 type sequence C description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 5) chain A residue 578 type sequence C description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 6) chain A residue 585 type sequence C description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 7) chain A residue 590 type sequence C description BINDING SITE FOR RESIDUE ZN A 802 source : AC2 8) chain A residue 565 type sequence C description BINDING SITE FOR RESIDUE ZN A 803 source : AC3 9) chain A residue 567 type sequence C description BINDING SITE FOR RESIDUE ZN A 803 source : AC3 10) chain A residue 571 type sequence C description BINDING SITE FOR RESIDUE ZN A 803 source : AC3 11) chain A residue 576 type sequence C description BINDING SITE FOR RESIDUE ZN A 803 source : AC3 12) chain A residue 571 type sequence C description BINDING SITE FOR RESIDUE ZN A 804 source : AC4 13) chain A residue 585 type sequence C description BINDING SITE FOR RESIDUE ZN A 804 source : AC4 14) chain A residue 593 type sequence C description BINDING SITE FOR RESIDUE ZN A 804 source : AC4 15) chain A residue 606 type sequence C description BINDING SITE FOR RESIDUE ZN A 804 source : AC4 16) chain A residue 528 type sequence C description BINDING SITE FOR RESIDUE ZN A 805 source : AC5 17) chain A residue 541 type sequence C description BINDING SITE FOR RESIDUE ZN A 805 source : AC5 18) chain A residue 548 type sequence C description BINDING SITE FOR RESIDUE ZN A 805 source : AC5 19) chain A residue 552 type sequence C description BINDING SITE FOR RESIDUE ZN A 805 source : AC5 20) chain A residue 528 type sequence C description BINDING SITE FOR RESIDUE ZN A 806 source : AC6 21) chain A residue 530 type sequence H description BINDING SITE FOR RESIDUE ZN A 806 source : AC6 22) chain A residue 535 type sequence C description BINDING SITE FOR RESIDUE ZN A 806 source : AC6 23) chain A residue 539 type sequence C description BINDING SITE FOR RESIDUE ZN A 806 source : AC6 24) chain A residue 535 type sequence C description BINDING SITE FOR RESIDUE ZN A 807 source : AC7 25) chain A residue 548 type sequence C description BINDING SITE FOR RESIDUE ZN A 807 source : AC7 26) chain A residue 554 type sequence C description BINDING SITE FOR RESIDUE ZN A 807 source : AC7 27) chain A residue 558 type sequence C description BINDING SITE FOR RESIDUE ZN A 807 source : AC7 28) chain A residue 639 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 source Swiss-Prot : SWS_FT_FI1

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