eF-site ID 4mha-B PDB Code 4mha Chain B click to enlarge Title Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase Mer Source Homo sapiens (Human) (MERTK_HUMAN) Sequence B:  LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKV AVKTMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKY GDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSN RNFLHRDLAARNCMLRDDMTVCVADFPVKWIAIESLADRV YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHG HRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK LLESLP Description Functional site 1) chain B residue 687 type sequence R description BINDING SITE FOR RESIDUE CL A 901 source : AC1 2) chain B residue 802 type sequence P description BINDING SITE FOR RESIDUE CL B 901 source : AC5 3) chain B residue 819 type sequence L description BINDING SITE FOR RESIDUE CL B 901 source : AC5 4) chain B residue 820 type sequence K description BINDING SITE FOR RESIDUE CL B 901 source : AC5 5) chain B residue 682 type sequence Y description BINDING SITE FOR RESIDUE CL B 902 source : AC6 6) chain B residue 584 type sequence R description BINDING SITE FOR RESIDUE CL B 903 source : AC7 7) chain B residue 588 type sequence I description BINDING SITE FOR RESIDUE CL B 903 source : AC7 8) chain B residue 589 type sequence L description BINDING SITE FOR RESIDUE CL B 903 source : AC7 9) chain B residue 728 type sequence N description BINDING SITE FOR RESIDUE MG B 904 source : AC8 10) chain B residue 741 type sequence D description BINDING SITE FOR RESIDUE MG B 904 source : AC8 11) chain B residue 593 type sequence L description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 12) chain B residue 594 type sequence G description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 13) chain B residue 595 type sequence E description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 14) chain B residue 603 type sequence E description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 15) chain B residue 617 type sequence A description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 16) chain B residue 650 type sequence I description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 17) chain B residue 671 type sequence L description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 18) chain B residue 672 type sequence P description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 19) chain B residue 674 type sequence M description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 20) chain B residue 675 type sequence K description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 21) chain B residue 730 type sequence M description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 22) chain B residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 23) chain B residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 24) chain B residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2

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