eF-site ID 4mha-AB PDB Code 4mha Chain A, B click to enlarge Title Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 Classification TRANSFERASE/TRANSFERASE INHIBITOR Compound Tyrosine-protein kinase Mer Source Homo sapiens (Human) (MERTK_HUMAN) Sequence A:  VVIDRNLLILGKILGEGSVMEGNLKQEDGTSLKVAVKTMK LDNSSQREIEEFLSEAACMKDFSHPNVIRLLGVCIEPKPM VILPFMKYGDLHTYLLYSRLETGPKHIPLQTLLKFMVDIA LGMEYLSNRNFLHRDLAARNCMLRDDMTVCVADFGPVKWI AIESLADRVYTSKSDVWAFGVTMWEIATRGMTPYPGVQNH EMYDYLLHGHRLKQPEDCLDELYEIMYSCWRTDPLDRPTF SVLRLQLEKLLESLPD B:  LEDVVIDRNLLILGKILGEGEFGSVMEGNLKQEDGTSLKV AVKTMKDFSHPNVIRLLGVCIEMSSQGIPKPMVILPFMKY GDLHTYLLYSRLETGPKHIPLQTLLKFMVDIALGMEYLSN RNFLHRDLAARNCMLRDDMTVCVADFPVKWIAIESLADRV YTSKSDVWAFGVTMWEIATRGMTPYPGVQNHEMYDYLLHG HRLKQPEDCLDELYEIMYSCWRTDPLDRPTFSVLRLQLEK LLESLP Description Functional site 1) chain A residue 797 type sequence G description BINDING SITE FOR RESIDUE CL A 901 source : AC1 2) chain B residue 687 type sequence R description BINDING SITE FOR RESIDUE CL A 901 source : AC1 3) chain A residue 802 type sequence P description BINDING SITE FOR RESIDUE CL A 902 source : AC2 4) chain A residue 819 type sequence L description BINDING SITE FOR RESIDUE CL A 902 source : AC2 5) chain A residue 820 type sequence K description BINDING SITE FOR RESIDUE CL A 902 source : AC2 6) chain A residue 584 type sequence R description BINDING SITE FOR RESIDUE CL A 903 source : AC3 7) chain A residue 589 type sequence L description BINDING SITE FOR RESIDUE CL A 903 source : AC3 8) chain A residue 593 type sequence L description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 9) chain A residue 617 type sequence A description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 10) chain A residue 650 type sequence I description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 11) chain A residue 672 type sequence P description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 12) chain A residue 673 type sequence F description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 13) chain A residue 674 type sequence M description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 14) chain A residue 675 type sequence K description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 15) chain A residue 677 type sequence G description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 16) chain A residue 730 type sequence M description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 17) chain A residue 741 type sequence D description BINDING SITE FOR RESIDUE 4MH A 904 source : AC4 18) chain B residue 802 type sequence P description BINDING SITE FOR RESIDUE CL B 901 source : AC5 19) chain B residue 819 type sequence L description BINDING SITE FOR RESIDUE CL B 901 source : AC5 20) chain B residue 820 type sequence K description BINDING SITE FOR RESIDUE CL B 901 source : AC5 21) chain B residue 682 type sequence Y description BINDING SITE FOR RESIDUE CL B 902 source : AC6 22) chain B residue 584 type sequence R description BINDING SITE FOR RESIDUE CL B 903 source : AC7 23) chain B residue 588 type sequence I description BINDING SITE FOR RESIDUE CL B 903 source : AC7 24) chain B residue 589 type sequence L description BINDING SITE FOR RESIDUE CL B 903 source : AC7 25) chain B residue 728 type sequence N description BINDING SITE FOR RESIDUE MG B 904 source : AC8 26) chain B residue 741 type sequence D description BINDING SITE FOR RESIDUE MG B 904 source : AC8 27) chain B residue 593 type sequence L description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 28) chain B residue 594 type sequence G description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 29) chain B residue 595 type sequence E description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 30) chain B residue 603 type sequence E description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 31) chain B residue 617 type sequence A description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 32) chain B residue 650 type sequence I description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 33) chain B residue 671 type sequence L description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 34) chain B residue 672 type sequence P description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 35) chain B residue 674 type sequence M description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 36) chain B residue 675 type sequence K description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 37) chain B residue 730 type sequence M description BINDING SITE FOR RESIDUE 4MH B 905 source : AC9 38) chain A residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 39) chain B residue 723 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10028 source Swiss-Prot : SWS_FT_FI1 40) chain B residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 41) chain B residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 42) chain A residue 593 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 43) chain A residue 615 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 44) chain A residue 593-619 type prosite sequence LGEGSVMEGNLKQEDGTSLKVAVK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGEFGSVMeGnlkqedgtslk.......VAVK source prosite : PS00107 45) chain A residue 719-731 type prosite sequence FLHRDLAARNCML description PROTEIN_KINASE_TYR Tyrosine protein kinases specific active-site signature. FLHrDLAARNCML source prosite : PS00109

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