eF-site ID 4mb8-A PDB Code 4mb8 Chain A click to enlarge Title Evolutionary history and metabolic insights of ancient mammalian uricases Classification OXIDOREDUCTASE Compound Uricase Source (4MB8) Sequence A:  VEFVRTGYGKDMVKVLHIQRDGKYHSIKEVATSVQLTLSS KKDYLHGDNSDIIPTDTIKNTVHVLAKFKGIKSIEAFAMN ICEHFLSSFNHVIRAQVYVEEVPWKRFEKNGVKHVHAFIH TPTGTHFCEVEQMKSGPPVIHSGIKDLKVLKTTQSGFEGF IKDQFTTLPEVKDRCFATQVYCKWRYHQGRDVDFEATWDT VRDIVLKKFAGPYDKGEYSPSVQKTLYDIQVLSLSRVPEI EDMEISLPNIHYFNIDMSKMGLINKEEVLLPLDNPYGKIT GTVKR Description Functional site 1) chain A residue 46 type sequence S description BINDING SITE FOR RESIDUE ACT B 401 source : AC1 2) chain A residue 109 type sequence Q description BINDING SITE FOR RESIDUE ACT B 401 source : AC1 3) chain A residue 23 type ACT_SITE sequence K description Charge relay system => ECO:0000250|UniProtKB:D0VWQ1 source Swiss-Prot : SWS_FT_FI1 4) chain A residue 68 type ACT_SITE sequence T description Charge relay system => ECO:0000250|UniProtKB:D0VWQ1 source Swiss-Prot : SWS_FT_FI1 5) chain A residue 264 type ACT_SITE sequence H description Charge relay system => ECO:0000250|UniProtKB:D0VWQ1 source Swiss-Prot : SWS_FT_FI1 6) chain A residue 68 type BINDING sequence T description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 7) chain A residue 69 type BINDING sequence D description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 8) chain A residue 170 type BINDING sequence F description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 9) chain A residue 187 type BINDING sequence R description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 10) chain A residue 235 type BINDING sequence V description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 11) chain A residue 236 type BINDING sequence Q description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 12) chain A residue 262 type BINDING sequence N description BINDING => ECO:0000250|UniProtKB:Q00511 source Swiss-Prot : SWS_FT_FI2 13) chain A residue 23 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI4 14) chain A residue 221 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI4 15) chain A residue 228 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI4 16) chain A residue 27 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 17) chain A residue 36 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 18) chain A residue 118 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 19) chain A residue 122 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 20) chain A residue 164 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 21) chain A residue 175 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 22) chain A residue 185 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 23) chain A residue 278 type MOD_RES sequence K description N6-acetyllysine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI5 24) chain A residue 39 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI6 25) chain A residue 63 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI6 26) chain A residue 232 type MOD_RES sequence S description Phosphoserine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 289 type MOD_RES sequence Y description Phosphotyrosine => ECO:0000250|UniProtKB:P25688 source Swiss-Prot : SWS_FT_FI7 28) chain A residue 160-187 type prosite sequence LKVLKTTQSGFEGFIKDQFTTLPEVKDR description URICASE Uricase signature. LkVLKTTqSgFegFikdqFttLpevkdR source prosite : PS00366

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