eF-site ID 4ma8-CHL PDB Code 4ma8 Chain C, H, L click to enlarge Title Crystal structure of mouse prion protein complexed with Chlorpromazine Classification IMMUNE SYSTEM Compound Major prion protein Source Mus musculus (Mouse) (4MA8) Sequence C:  GAVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYP NQVYYRPVDQYSNQNNFVHDCVNITIKQHTVTTTTKGENF TETDVKMMERVVEQMCVTQYQKESQAYY H:  QVQLQQSGTELVMPGASVKMSCKASGYTFTDYWMHWVKQR PGQGLEWIGSIDPSDSYTSHNEKFKGKATLTVDESSSTAY MQLSSLTSEDSAVYFCSRSGYGYYAMEYWGQGTSVTVSSA KTTPPSVYPLAPGGGATNSMVTLGCLVKGYFPEPVTVTWN SGSLSGGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTC NVAHPASSTKVDKKIVPR L:  DIVLTQSPAILSVSPGERVSFSCRASQNIGTSIHWYQQRT NESPRLIIKYASESISGIPSRFSGSGSGTDFTLSINSVES EDIADYYCQQSNTWPYTFGGGTKLELKRADAAPTVSIFPP SSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVL NSETDQDSKDSTYSMSSTLTLTKDEYERHNTYTCEATHKT STSPIVKSFNRNE Description Functional site 1) chain C residue 125 type sequence L description BINDING SITE FOR RESIDUE Z80 C 301 source : AC1 2) chain C residue 182 type sequence I description BINDING SITE FOR RESIDUE Z80 C 301 source : AC1 3) chain C residue 185 type sequence K description BINDING SITE FOR RESIDUE Z80 C 301 source : AC1 4) chain C residue 186 type sequence Q description BINDING SITE FOR RESIDUE Z80 C 301 source : AC1 5) chain C residue 197 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19349973 source Swiss-Prot : SWS_FT_FI2 6) chain C residue 181 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000305 source Swiss-Prot : SWS_FT_FI1 7) chain L residue 192-198 type prosite sequence YTCEATH description IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH source prosite : PS00290 8) chain C residue 200-218 type prosite sequence ETDVKMMERVVEQMCVTQY description PRION_2 Prion protein signature 2. EtDvKMMeRVVeQMCvtQY source prosite : PS00706

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