eF-site ID 4m0w-AB PDB Code 4m0w Chain A, B click to enlarge Title Crystal Structure of SARS-CoV papain-like protease C112S mutant in complex with ubiquitin Classification HYDROLASE/PROTEIN BINDING Compound Replicase polyprotein 1a Source ORGANISM_COMMON: bovine; ORGANISM_SCIENTIFIC: Bos taurus; Sequence A:  VKTIKVFTTVDNTNLHTQLVDMSMTYGQQFGPTYLDGADV TKIKPHVNHEGKTFFVLPSDDTLRSEAFEYYHTLDESFLG RYMSALNHTKKWKFPQVGGLTSIKWADNNSYLSSVLLALQ QLEVKFNAPALQEAYYRARAGDAANFCALILAYSNKTVGE LGDVRETMTHLLQHANLESAKRVLNVVCKHCGQKTTTLTG VEAVMYMGTLSYDNLKTGVSIPCVCGRDATQYLVQQESSF VMMSAPPAEYKLQQGTFLCANEYTGNYQCGHYTHITAKET LYRIDGAHLTKMSEYKGPVTDVFYKETSYTTTIKPVS B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLRLRGG Description Functional site 1) chain A residue 190 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 2) chain A residue 193 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 3) chain A residue 225 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 4) chain A residue 227 type sequence C description BINDING SITE FOR RESIDUE ZN A 401 source : AC1 5) chain A residue 112 type sequence S description BINDING SITE FOR RESIDUE NA A 402 source : AC2 6) chain A residue 115 type sequence S description BINDING SITE FOR RESIDUE NA A 402 source : AC2 7) chain A residue 116 type sequence S description BINDING SITE FOR RESIDUE NA A 402 source : AC2 8) chain A residue 274 type sequence Y description BINDING SITE FOR RESIDUE NA A 402 source : AC2 9) chain A residue 106 type sequence K description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 10) chain A residue 107 type sequence W description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 11) chain A residue 287 type sequence D description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 12) chain A residue 288 type sequence G description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 13) chain A residue 289 type sequence A description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 14) chain A residue 290 type sequence H description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 15) chain A residue 313 type sequence T description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 16) chain A residue 315 type sequence I description BINDING SITE FOR RESIDUE NHE A 403 source : AC3 17) chain A residue 123 type sequence Q description BINDING SITE FOR RESIDUE NHE A 404 source : AC4 18) chain A residue 124 type sequence L description BINDING SITE FOR RESIDUE NHE A 404 source : AC4 19) chain A residue 125 type sequence E description BINDING SITE FOR RESIDUE NHE A 404 source : AC4 20) chain A residue 141 type sequence R description BINDING SITE FOR RESIDUE NHE A 404 source : AC4 21) chain A residue 18 type sequence H description BINDING SITE FOR RESIDUE GOL A 405 source : AC5 22) chain A residue 20 type sequence Q description BINDING SITE FOR RESIDUE GOL A 405 source : AC5 23) chain A residue 62 type sequence D description BINDING SITE FOR RESIDUE GOL A 405 source : AC5 24) chain A residue 64 type sequence T description BINDING SITE FOR RESIDUE GOL A 405 source : AC5 25) chain A residue 65 type sequence L description BINDING SITE FOR RESIDUE GOL A 405 source : AC5 26) chain A residue 252 type sequence Y description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 27) chain A residue 253 type sequence K description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 28) chain A residue 254 type sequence L description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 29) chain A residue 255 type sequence Q description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 30) chain A residue 258 type sequence T description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 31) chain A residue 306 type sequence Y description BINDING SITE FOR RESIDUE GOL A 406 source : AC6 32) chain B residue 24 type sequence E description BINDING SITE FOR RESIDUE GOL B 101 source : AC7 33) chain B residue 25 type sequence N description BINDING SITE FOR RESIDUE GOL B 101 source : AC7 34) chain B residue 28 type sequence A description BINDING SITE FOR RESIDUE GOL B 101 source : AC7 35) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI3 36) chain A residue 287 type MOD_RES sequence D description Phosphoserine; by PINK1 => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI3 37) chain B residue 76 type MOD_RES sequence G description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI4 38) chain A residue 193 type MOD_RES sequence C description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI4 39) chain A residue 225 type MOD_RES sequence C description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI4 40) chain A residue 227 type MOD_RES sequence C description ADP-ribosylglycine => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI4 41) chain B residue 76 type CROSSLNK sequence G description Glycyl lysine isopeptide (Gly-Lys) (interchain with K-? in acceptor proteins) source Swiss-Prot : SWS_FT_FI6 42) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 43) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 44) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 45) chain B residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299 46) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 47) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 48) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 49) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 50) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 51) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5 52) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000250|UniProtKB:P62979 source Swiss-Prot : SWS_FT_FI5

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