eF-site ID 4lwp-AB PDB Code 4lwp Chain A, B click to enlarge Title Crystal structure of PRMT6-SAH Classification TRANSFERASE Compound Arginine N-methyltransferase, putative Source Trypanosoma brucei brucei (strain 927/4 GUTat10.1) (Q57U70_TRYB2) Sequence A:  DLAVHRLMLEDAQRMSFYRKSIEQSASIEGKVVVDVGSGT GILSMWAARAGAKHVFSIEASSLSEFQIGVVEDNDLSTKI TVLGDTVENIIAGGVANFVNRHKAKLGKCGVAVLLSEWMG FYLFHEGMLPSVIRARNFFQDVNAALGVLQPIEMIPERAT VFVAPITCKPYYVQRYKNFWRDVDGLDFSRYGRIEYEVYL EQPLVECLPPLCLLHEGLSLIELNLSTVQEEVLTSLHNTV HFDLKESAEFQQHAREAGSEGRVSVDGFTVWFDVSYGAHT LSTSPRSPSTHWKQTTILLPREARNEELVSFPVEGGELGV EMHISASDKTLRFYTIELELK B:  SDLAVHRLMLEDAQRMSFYRKSIEQSASIEGKVVVDVGSG TGILSMWAARAGAKHVFSIEASSLSEFQIGVVEDNDLSTK ITVLGDTVENIIAGGVANFVNRHKAKLGKCGVAVLLSEWM GFYLFHEGMLPSVIRARNFFQDVNAALGVLQPIEMIPERA TVFVAPITCKPYYVQRYKNFWRDVDGLDFSRYGRIEYEVY LEQPLVECLPPLCLLHEGLSLIELNLSTVQEEVLTSLHNT VHFDLKESAEFQQHAREAGSEGRVSVDGFTVWFDVSYGAH TLSTSPRSPSTHWKQTTILLPREARNEELVSFPVEGGELG VEMHISASDKTLRFYTIELELK Description Functional site 1) chain B residue 185 type sequence T description BINDING SITE FOR RESIDUE IOD B 401 source : AC1 2) chain B residue 302 type sequence S description BINDING SITE FOR RESIDUE IOD B 401 source : AC1 3) chain B residue 251 type sequence N description BINDING SITE FOR RESIDUE IOD B 402 source : AC2 4) chain B residue 126 type sequence R description BINDING SITE FOR RESIDUE IOD B 404 source : AC3 5) chain B residue 127 type sequence H description BINDING SITE FOR RESIDUE IOD B 404 source : AC3 6) chain B residue 318 type sequence H description BINDING SITE FOR RESIDUE IOD B 405 source : AC4 7) chain B residue 30 type sequence H description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 8) chain B residue 39 type sequence R description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 9) chain B residue 62 type sequence G description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 10) chain B residue 63 type sequence S description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 11) chain B residue 64 type sequence G description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 12) chain B residue 67 type sequence I description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 13) chain B residue 84 type sequence E description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 14) chain B residue 85 type sequence A description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 15) chain B residue 110 type sequence D description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 16) chain B residue 111 type sequence T description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 17) chain B residue 112 type sequence V description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 18) chain B residue 113 type sequence E description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 19) chain B residue 142 type sequence E description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 20) chain B residue 153 type sequence M description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 21) chain B residue 156 type sequence S description BINDING SITE FOR RESIDUE SAH B 407 source : AC5 22) chain A residue 30 type sequence H description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 23) chain A residue 33 type sequence M description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 24) chain A residue 39 type sequence R description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 25) chain A residue 62 type sequence G description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 26) chain A residue 63 type sequence S description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 27) chain A residue 64 type sequence G description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 28) chain A residue 84 type sequence E description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 29) chain A residue 85 type sequence A description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 30) chain A residue 110 type sequence D description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 31) chain A residue 111 type sequence T description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 32) chain A residue 112 type sequence V description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 33) chain A residue 113 type sequence E description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 34) chain A residue 142 type sequence E description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 35) chain A residue 153 type sequence M description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 36) chain A residue 156 type sequence S description BINDING SITE FOR RESIDUE SAH A 401 source : AC6 37) chain A residue 185 type sequence T description BINDING SITE FOR RESIDUE IOD A 402 source : AC7 38) chain A residue 302 type sequence S description BINDING SITE FOR RESIDUE IOD A 402 source : AC7 39) chain B residue 268 type sequence H description BINDING SITE FOR RESIDUE IOD A 403 source : AC8 40) chain A residue 127 type sequence H description BINDING SITE FOR RESIDUE IOD A 404 source : AC9 41) chain A residue 195 type sequence P description BINDING SITE FOR RESIDUE PGE A 405 source : BC1 42) chain A residue 199 type sequence Q description BINDING SITE FOR RESIDUE PGE A 405 source : BC1 43) chain A residue 238 type sequence L description BINDING SITE FOR RESIDUE PGE A 405 source : BC1 44) chain A residue 283 type sequence E description BINDING SITE FOR RESIDUE PGE A 405 source : BC1

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