eF-site ID 4luv-A
PDB Code 4luv
Chain A

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Title Fragment-Based Discovery of a Potent Inhibitor of Replication Protein A Protein-Protein Interactions
Classification DNA BINDING protein/inhibitor
Compound Replication protein A 70 kDa DNA-binding subunit
Source Homo sapiens (Human) (RFA1_HUMAN)
Sequence A:  GSHMVGQLSRGAIAAIMQKGDTNIKPILQVINIRPITTGN
SPPRYRLLMSDGLNTLSSFMLATQLNPLVEEEQLSSNCVC
QIHRFIVNTLKDGRRVVILMELEVLKSAEAVGVKIGNPVP
YNE
Description


Functional site

1) chain A
residue 41
type
sequence R
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

2) chain A
residue 57
type
sequence M
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

3) chain A
residue 59
type
sequence A
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

4) chain A
residue 60
type
sequence T
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

5) chain A
residue 85
type
sequence N
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

6) chain A
residue 95
type
sequence I
description BINDING SITE FOR RESIDUE 1XS A 201
source : AC1

7) chain A
residue 31
type
sequence R
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

8) chain A
residue 33
type
sequence I
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

9) chain A
residue 34
type
sequence T
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

10) chain A
residue 43
type
sequence R
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

11) chain A
residue 55
type
sequence S
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

12) chain A
residue 57
type
sequence M
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

13) chain A
residue 93
type
sequence V
description BINDING SITE FOR RESIDUE 1DZ A 202
source : AC2

14) chain A
residue 22
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068
source Swiss-Prot : SWS_FT_FI2

15) chain A
residue 88
type CROSSLNK
sequence K
description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:26474068
source Swiss-Prot : SWS_FT_FI2

16) chain A
residue 1
type MOD_RES
sequence M
description N-acetylmethionine => ECO:0007744|PubMed:19413330, ECO:0007744|PubMed:22223895
source Swiss-Prot : SWS_FT_FI1


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