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|
eF-site ID
|
4ltc-V |
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PDB Code
|
4ltc |
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Chain
|
V |
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click to enlarge
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Title
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Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6 |
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Classification
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Hydrolase/Hydrolase Inhibitor |
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Compound
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Proteasome subunit alpha type-2 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
|
V: |
TTIVGVKFNNGVVIAADTRSTQGPIVADKNCAKLHRISPK
IWCAGAGTAADTEAVTQLIGSNIELHSLYTSREPRVVSAL
QMLKQHLFKYQGHIGAYLIVAGVDPTGSHLFSIHAHGSTD
VGYYLSLGSGSLAAMAVLESHWKQDLTKEEAIKLASDAIQ
AGIWNDLGSGSNVDVCVMEIGKDAEYLRNYLTPNVREEKQ
KSYKFPRGTTAVLKESIVNICD
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Description
|
(1) |
Proteasome subunit alpha type-2 (E.C.3.4.25.1), Proteasome subunit alpha type-3 (E.C.3.4.25.1), Proteasome subunit alpha type-4 (E.C.3.4.25.1), Proteasome subunit alpha type-5 (E.C.3.4.25.1), Proteasome subunit alpha type-6 (E.C.3.4.25.1), Probable proteasome subunit alpha type-7 (E.C.3.4.25.1), Proteasome subunit alpha type-1 (E.C.3.4.25.1), Proteasome subunit beta type-2 (E.C.3.4.25.1), Proteasome subunit beta type-3 (E.C.3.4.25.1), Proteasome subunit beta type-4 (E.C.3.4.25.1), Proteasome subunit beta type-5 (E.C.3.4.25.1), Proteasome subunit beta type-6 (E.C.3.4.25.1), Proteasome subunit beta type-7 (E.C.3.4.25.1), Proteasome subunit beta type-1 (E.C.3.4.25.1)
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Functional site
|
|
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1)
|
chain |
V |
| residue |
1 |
| type |
catalytic |
| sequence |
T
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
2)
|
chain |
V |
| residue |
17 |
| type |
catalytic |
| sequence |
D
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
3)
|
chain |
V |
| residue |
19 |
| type |
catalytic |
| sequence |
R
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
4)
|
chain |
V |
| residue |
33 |
| type |
catalytic |
| sequence |
K
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
5)
|
chain |
V |
| residue |
47 |
| type |
catalytic |
| sequence |
G
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
6)
|
chain |
V |
| residue |
129 |
| type |
catalytic |
| sequence |
S
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
7)
|
chain |
V |
| residue |
166 |
| type |
catalytic |
| sequence |
D
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
8)
|
chain |
V |
| residue |
169 |
| type |
catalytic |
| sequence |
S
|
| description |
177
|
| source |
MCSA : MCSA2
|
|
|
|