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eF-site ID
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4ltc-K |
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PDB Code
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4ltc |
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Chain
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K |
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click to enlarge
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Title
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Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6 |
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Classification
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Hydrolase/Hydrolase Inhibitor |
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Compound
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Proteasome subunit alpha type-2 |
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Source
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ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
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Sequence
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K: |
TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF
LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS
KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT
RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS
ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG
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Description
|
(1) |
Proteasome subunit alpha type-2 (E.C.3.4.25.1), Proteasome subunit alpha type-3 (E.C.3.4.25.1), Proteasome subunit alpha type-4 (E.C.3.4.25.1), Proteasome subunit alpha type-5 (E.C.3.4.25.1), Proteasome subunit alpha type-6 (E.C.3.4.25.1), Probable proteasome subunit alpha type-7 (E.C.3.4.25.1), Proteasome subunit alpha type-1 (E.C.3.4.25.1), Proteasome subunit beta type-2 (E.C.3.4.25.1), Proteasome subunit beta type-3 (E.C.3.4.25.1), Proteasome subunit beta type-4 (E.C.3.4.25.1), Proteasome subunit beta type-5 (E.C.3.4.25.1), Proteasome subunit beta type-6 (E.C.3.4.25.1), Proteasome subunit beta type-7 (E.C.3.4.25.1), Proteasome subunit beta type-1 (E.C.3.4.25.1)
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Functional site
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1)
|
chain |
K |
| residue |
1 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
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2)
|
chain |
K |
| residue |
19 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
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3)
|
chain |
K |
| residue |
20 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
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|
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4)
|
chain |
K |
| residue |
21 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
|
|
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5)
|
chain |
K |
| residue |
27 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
|
|
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6)
|
chain |
K |
| residue |
47 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
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|
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7)
|
chain |
K |
| residue |
49 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
|
|
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8)
|
chain |
K |
| residue |
96 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
|
|
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9)
|
chain |
K |
| residue |
131 |
| type |
|
| sequence |
S
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
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|
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10)
|
chain |
K |
| residue |
170 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE EC6 K 301
|
| source |
: AC1
|
|
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11)
|
chain |
K |
| residue |
49 |
| type |
BINDING |
| sequence |
A
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
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|
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12)
|
chain |
K |
| residue |
4-51 |
| type |
prosite |
| sequence |
LAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPFLLG
TMAGGAAD
|
| description |
PROTEASOME_BETA_1 Proteasome beta-type subunits signature. VGVkFnnGVVIAADtrstqgpivadknca.KlhrispkiwcagaGtaAD
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| source |
prosite : PS00854
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