|
|
eF-site ID
|
4ltc-Y |
|
PDB Code
|
4ltc |
|
Chain
|
Y |
|
click to enlarge
|
|
|
Title
|
Crystal structure of yeast 20S proteasome in complex with enone carmaphycin analogue 6 |
|
Classification
|
Hydrolase/Hydrolase Inhibitor |
|
Compound
|
Proteasome subunit alpha type-2 |
|
Source
|
ORGANISM_COMMON: Baker's yeast; ORGANISM_SCIENTIFIC: Saccharomyces cerevisiae; |
|
|
Sequence
|
Y: |
TTTLAFRFQGGIIVAVDSRATAGNWVASQTVKKVIEINPF
LLGTMAGGAADCQFWETWLGSQCRLHELREKERISVAAAS
KILSNLVYQYKGAGLSMGTMICGYTRKEGPTIYYVDSDGT
RLKGDIFCVGSGQTFAYGVLDSNYKWDLSVEDALYLGKRS
ILAAAHRDAYSGGSVNLYHVTEDGWIYHGNHDVGELFWKV
KEEEGSFNNVIG
|
|
|
Description
|
(1) |
Proteasome subunit alpha type-2 (E.C.3.4.25.1), Proteasome subunit alpha type-3 (E.C.3.4.25.1), Proteasome subunit alpha type-4 (E.C.3.4.25.1), Proteasome subunit alpha type-5 (E.C.3.4.25.1), Proteasome subunit alpha type-6 (E.C.3.4.25.1), Probable proteasome subunit alpha type-7 (E.C.3.4.25.1), Proteasome subunit alpha type-1 (E.C.3.4.25.1), Proteasome subunit beta type-2 (E.C.3.4.25.1), Proteasome subunit beta type-3 (E.C.3.4.25.1), Proteasome subunit beta type-4 (E.C.3.4.25.1), Proteasome subunit beta type-5 (E.C.3.4.25.1), Proteasome subunit beta type-6 (E.C.3.4.25.1), Proteasome subunit beta type-7 (E.C.3.4.25.1), Proteasome subunit beta type-1 (E.C.3.4.25.1)
|
|
Functional site
|
|
|
1)
|
chain |
Y |
| residue |
1 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
2)
|
chain |
Y |
| residue |
19 |
| type |
|
| sequence |
R
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
3)
|
chain |
Y |
| residue |
20 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
4)
|
chain |
Y |
| residue |
21 |
| type |
|
| sequence |
T
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
5)
|
chain |
Y |
| residue |
47 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
6)
|
chain |
Y |
| residue |
48 |
| type |
|
| sequence |
G
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
7)
|
chain |
Y |
| residue |
49 |
| type |
|
| sequence |
A
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
8)
|
chain |
Y |
| residue |
170 |
| type |
|
| sequence |
Y
|
| description |
BINDING SITE FOR RESIDUE EC6 Y 301
|
| source |
: AC2
|
|
|
9)
|
chain |
Y |
| residue |
49 |
| type |
BINDING |
| sequence |
A
|
| description |
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
|