eF-site ID 4ll1-B PDB Code 4ll1 Chain B click to enlarge Title The structure of the TRX and TXNIP complex Classification ANTITUMOR PROTEIN/PROTEIN BINDING Compound Thioredoxin-interacting protein Source Homo sapiens (Human) (THIO_HUMAN) Sequence B:  MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPAKMIKP FFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFF KKGQKVGEFSGANKEKLEATINELV Description Functional site 1) chain B residue 3 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 2) chain B residue 39 type MOD_RES sequence K description N6-acetyllysine => ECO:0007744|PubMed:19608861 source Swiss-Prot : SWS_FT_FI4 3) chain B residue 26 type SITE sequence D description Deprotonates C-terminal active site Cys => ECO:0000305 source Swiss-Prot : SWS_FT_FI2 4) chain B residue 8 type MOD_RES sequence K description N6-succinyllysine => ECO:0000250|UniProtKB:P10639 source Swiss-Prot : SWS_FT_FI5 5) chain B residue 62 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:17260951 source Swiss-Prot : SWS_FT_FI6 6) chain B residue 69 type MOD_RES sequence C description S-nitrosocysteine => ECO:0000269|PubMed:17260951 source Swiss-Prot : SWS_FT_FI6 7) chain B residue 73 type MOD_RES sequence C description S-nitrosocysteine; alternate => ECO:0000269|PubMed:16408020, ECO:0000269|PubMed:17606900 source Swiss-Prot : SWS_FT_FI7 8) chain B residue 94 type MOD_RES sequence K description N6-succinyllysine; alternate => ECO:0000250|UniProtKB:P10639 source Swiss-Prot : SWS_FT_FI8 9) chain B residue 33 type SITE sequence G description Contributes to redox potential value => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 10) chain B residue 34 type SITE sequence P description Contributes to redox potential value => ECO:0000305 source Swiss-Prot : SWS_FT_FI3 11) chain B residue 32 type ACT_SITE sequence C description Nucleophile => ECO:0000269|PubMed:9108029 source Swiss-Prot : SWS_FT_FI1 12) chain B residue 35 type ACT_SITE sequence A description Nucleophile => ECO:0000269|PubMed:9108029 source Swiss-Prot : SWS_FT_FI1

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