eF-site ID 4lgy-A PDB Code 4lgy Chain A click to enlarge Title Importance of Hydrophobic Cavities in Allosteric Regulation of Formylglycinamide Synthetase: Insight from Xenon Trapping and Statistical Coupling Analysis Classification LIGASE Compound Phosphoribosylformylglycinamidine synthase Source Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720) (PUR4_SALTY) Sequence A:  GDGLVPRGSHMMEILRGSPALSAFRINKLLARFQAANLQV HNIYAEYVHFADLNAPLNDSEQAQLTRLLQYGPALSSHTP AGKLLLVTPRPGTISPWSSKATDIAHNCGLQQVDRLERGV AYYIEASTLTAEQWRQVAAELHDRMMETVFSSLTDAEKLF IHHQPAPVSSVDLLGEGRQALIDANLRLGLALAEDEIDYL QEAFTKLGRNPNDIELYMWAQANSEHCRHKIFNADWIIDG KPQPKSLFKMIKNTFETTPDYVLSAYKDNAAVMEGSAVGR YFADHNTGRYDFHQEPAHILMKVETHNHPTAISPWPGAAT GSGGEIRDEGATGRGAKPKAGLVGFSVSNLRIPGFEQPWE EDFGKPERIVTALDIMTEGPLGGAAFNNEFGRPALTGYFR TYEEKVNSHNGEELRGYHKPIMLAGGIGNIRADHVQKGEI VVGAKLIVLGGPAMNIGLDFASVQRDNPEMERRCQEVIDR CWQLGDANPILFIHDVGAGGLSNAMPELVSDGGRGGKFEL RDILSDEPGMSPLEIWCNESQERYVLAVAADQLPLFDELC KRERAPYAVIGDATEEQHLSLHDNHFDNQPIDLPLDVLLG KTPKMTRDVQTLKAKGDALNRADITIADAVKRVLHLPTVA EKTFLVTIGDRTVTGMVARDQMVGPWQVPVADCAVTTASL DSYYGEAMSIGERAPVALLDFAASARLAVGEALTNIAATQ IGDIKRIKLSANWMAAAGHPGEDAGLYDAVKAVGEELCPQ LGLTIPVGKDSMSMKTRWQEGNEQREMTSPLSLVISAFAR VEDVRHTLTPQLSTEDNALLLIDLGKGHNALGATALAQVY RQLGDKPADVRDVAQLKGFYDAMQALVAARKLLAWHDRSD GGLLVTLAEMAFAGHCGVQVDIAALGDDHLAALFNEELGG VIQVRAEDRDAVEALLAQYGLADCVHYLGQALAGDRFVIT ANDQTVFSESRTTLRVWWAETTWQMQRLRDNPQCADQEHE AKANDTDPGLNVKLSFDINEDIAAPYIATGARPKVAVLRE QGVNSHVEMAAAFHRAGFDAIDVHMSDLLGGRIGLGNFHA LVACGGFSYGDVLGAGEGWAKSILFNHRVRDEFETFFHRP QTLALGVXNGCQMMSNLRELIPGSELWPRFVRNHSDRFEA RFSLVEVTQSPSLLLQGMVGSQMPIAVSHGEGRVEVRDDA HLAALESKGLVALRYVDNFGKVTETYPANPNGSPNGITAV TTENGRVTIMMPHPERVFRTVANSWHPENWGEDSPWMRIF RNARKQLG Description Functional site 1) chain A residue 333 type sequence V description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 2) chain A residue 386 type sequence T description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 3) chain A residue 387 type sequence G description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 4) chain A residue 388 type sequence Y description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 5) chain A residue 389 type sequence F description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 6) chain A residue 649 type sequence K description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 7) chain A residue 652 type sequence L description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 8) chain A residue 653 type sequence V description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 9) chain A residue 668 type sequence Q description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 10) chain A residue 676 type sequence P description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 11) chain A residue 678 type sequence A description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 12) chain A residue 679 type sequence D description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 13) chain A residue 718 type sequence E description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 14) chain A residue 722 type sequence N description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 15) chain A residue 886 type sequence S description BINDING SITE FOR RESIDUE ADP A 1301 source : AC1 16) chain A residue 679 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 17) chain A residue 722 type sequence N description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 18) chain A residue 884 type sequence D description BINDING SITE FOR RESIDUE MG A 1302 source : AC2 19) chain A residue 718 type sequence E description BINDING SITE FOR RESIDUE MG A 1303 source : AC3 20) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 21) chain A residue 504 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 22) chain A residue 505 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 23) chain A residue 776 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1305 source : AC5 24) chain A residue 216 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 25) chain A residue 295 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 26) chain A residue 296 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 27) chain A residue 297 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 28) chain A residue 298 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 29) chain A residue 778 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1306 source : AC6 30) chain A residue 690 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 31) chain A residue 812 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 32) chain A residue 1228 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 33) chain A residue 1229 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1307 source : AC7 34) chain A residue 356 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 35) chain A residue 357 type sequence E description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 36) chain A residue 358 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1308 source : AC8 37) chain A residue 1040 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 38) chain A residue 1041 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 39) chain A residue 1086 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1309 source : AC9 40) chain A residue 833 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1310 source : BC1 41) chain A residue 835 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1310 source : BC1 42) chain A residue 858 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1310 source : BC1 43) chain A residue 305 type sequence W description BINDING SITE FOR RESIDUE SO4 A 1311 source : BC2 44) chain A residue 1159 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1311 source : BC2 45) chain A residue 1164 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1311 source : BC2 46) chain A residue 1086 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1312 source : BC3 47) chain A residue 1126 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1312 source : BC3 48) chain A residue 1127 type sequence P description BINDING SITE FOR RESIDUE SO4 A 1312 source : BC3 49) chain A residue 1128 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1312 source : BC3 50) chain A residue 1129 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1312 source : BC3 51) chain A residue 1176 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1313 source : BC4 52) chain A residue 1184 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1313 source : BC4 53) chain A residue 1185 type sequence M description BINDING SITE FOR RESIDUE SO4 A 1313 source : BC4 54) chain A residue 1186 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1313 source : BC4 55) chain A residue 911 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1314 source : BC5 56) chain A residue 953 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1314 source : BC5 57) chain A residue 767 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1315 source : BC6 58) chain A residue 859 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1315 source : BC6 59) chain A residue 860 type sequence V description BINDING SITE FOR RESIDUE SO4 A 1315 source : BC6 60) chain A residue 861 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1315 source : BC6 61) chain A residue 54 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 1316 source : BC7 62) chain A residue 1112 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1316 source : BC7 63) chain A residue 1114 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1316 source : BC7 64) chain A residue 196 type sequence K description BINDING SITE FOR RESIDUE SO4 A 1317 source : BC8 65) chain A residue 1113 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1317 source : BC8 66) chain A residue 1115 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1317 source : BC8 67) chain A residue 1251 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1318 source : BC9 68) chain A residue 1253 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1318 source : BC9 69) chain A residue 12 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1319 source : CC1 70) chain A residue 13 type sequence A description BINDING SITE FOR RESIDUE SO4 A 1319 source : CC1 71) chain A residue 14 type sequence F description BINDING SITE FOR RESIDUE SO4 A 1319 source : CC1 72) chain A residue 998 type sequence N description BINDING SITE FOR RESIDUE SO4 A 1319 source : CC1 73) chain A residue 1161 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1319 source : CC1 74) chain A residue 632 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1320 source : CC2 75) chain A residue 633 type sequence I description BINDING SITE FOR RESIDUE SO4 A 1320 source : CC2 76) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1321 source : CC3 77) chain A residue 69 type sequence T description BINDING SITE FOR RESIDUE SO4 A 1321 source : CC3 78) chain A residue -1 type sequence S description BINDING SITE FOR RESIDUE SO4 A 1322 source : CC4 79) chain A residue -3 type sequence R description BINDING SITE FOR RESIDUE SO4 A 1322 source : CC4 80) chain A residue -2 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1322 source : CC4 81) chain A residue 152 type sequence H description BINDING SITE FOR RESIDUE SO4 A 1322 source : CC4 82) chain A residue 913 type sequence G description BINDING SITE FOR RESIDUE SO4 A 1323 source : CC5 83) chain A residue 914 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1323 source : CC5 84) chain A residue 915 type sequence D description BINDING SITE FOR RESIDUE SO4 A 1323 source : CC5 85) chain A residue 432 type sequence V description BINDING SITE FOR RESIDUE ACT A 1324 source : CC6 86) chain A residue 581 type sequence T description BINDING SITE FOR RESIDUE ACT A 1324 source : CC6 87) chain A residue 582 type sequence E description BINDING SITE FOR RESIDUE ACT A 1324 source : CC6 88) chain A residue 583 type sequence E description BINDING SITE FOR RESIDUE ACT A 1324 source : CC6 89) chain A residue 108 type sequence R description BINDING SITE FOR RESIDUE ACT A 1325 source : CC7 90) chain A residue 247 type sequence T description BINDING SITE FOR RESIDUE ACT A 1326 source : CC8 91) chain A residue 638 type sequence K description BINDING SITE FOR RESIDUE ACT A 1326 source : CC8 92) chain A residue 984 type sequence W description BINDING SITE FOR RESIDUE ACT A 1326 source : CC8 93) chain A residue 689 type sequence S description BINDING SITE FOR RESIDUE GOL A 1327 source : CC9 94) chain A residue 691 type sequence Y description BINDING SITE FOR RESIDUE GOL A 1327 source : CC9 95) chain A residue 1229 type sequence V description BINDING SITE FOR RESIDUE GOL A 1327 source : CC9 96) chain A residue 1230 type sequence T description BINDING SITE FOR RESIDUE GOL A 1327 source : CC9 97) chain A residue 1231 type sequence E description BINDING SITE FOR RESIDUE GOL A 1327 source : CC9 98) chain A residue 902 type sequence H description BINDING SITE FOR RESIDUE GOL A 1328 source : DC1 99) chain A residue 903 type sequence C description BINDING SITE FOR RESIDUE GOL A 1328 source : DC1 100) chain A residue 961 type sequence G description BINDING SITE FOR RESIDUE GOL A 1328 source : DC1 101) chain A residue 978 type sequence R description BINDING SITE FOR RESIDUE GOL A 1328 source : DC1 102) chain A residue 1012 type sequence D description BINDING SITE FOR RESIDUE GOL A 1328 source : DC1 103) chain A residue 264 type sequence E description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 104) chain A residue 267 type sequence A description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 105) chain A residue 286 type sequence P description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 106) chain A residue 1003 type sequence D description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 107) chain A residue 1004 type sequence Q description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 108) chain A residue 1007 type sequence E description BINDING SITE FOR RESIDUE GOL A 1329 source : DC2 109) chain A residue 84 type sequence I description BINDING SITE FOR RESIDUE GOL A 1330 source : DC3 110) chain A residue 85 type sequence S description BINDING SITE FOR RESIDUE GOL A 1330 source : DC3 111) chain A residue 86 type sequence P description BINDING SITE FOR RESIDUE GOL A 1330 source : DC3 112) chain A residue 136 type sequence M description BINDING SITE FOR RESIDUE GOL A 1330 source : DC3 113) chain A residue 472 type sequence R description BINDING SITE FOR RESIDUE GOL A 1330 source : DC3 114) chain A residue 52 type sequence Q description BINDING SITE FOR RESIDUE CL A 1331 source : DC4 115) chain A residue 53 type sequence A description BINDING SITE FOR RESIDUE CL A 1331 source : DC4 116) chain A residue 1173 type sequence E description BINDING SITE FOR RESIDUE CL A 1332 source : DC5 117) chain A residue 1174 type sequence V description BINDING SITE FOR RESIDUE CL A 1332 source : DC5 118) chain A residue 1272 type sequence W description BINDING SITE FOR RESIDUE CL A 1333 source : DC6 119) chain A residue 1273 type sequence H description BINDING SITE FOR RESIDUE CL A 1333 source : DC6 120) chain A residue 1102 type sequence A description BINDING SITE FOR RESIDUE CL A 1334 source : DC7 121) chain A residue 1143 type sequence N description BINDING SITE FOR RESIDUE CL A 1334 source : DC7 122) chain A residue 1157 type sequence F description BINDING SITE FOR RESIDUE CL A 1334 source : DC7 123) chain A residue 1124 type sequence F description BINDING SITE FOR RESIDUE CL A 1335 source : DC8 124) chain A residue 1251 type sequence N description BINDING SITE FOR RESIDUE CL A 1335 source : DC8 125) chain A residue 1253 type sequence R description BINDING SITE FOR RESIDUE CL A 1335 source : DC8 126) chain A residue 384 type sequence A description BINDING SITE FOR RESIDUE CL A 1336 source : DC9 127) chain A residue 652 type sequence L description BINDING SITE FOR RESIDUE CL A 1336 source : DC9 128) chain A residue 1169 type sequence F description BINDING SITE FOR RESIDUE MG A 1337 source : EC1 129) chain A residue 267 type sequence A description BINDING SITE FOR RESIDUE MG A 1338 source : EC2 130) chain A residue 1231 type sequence E description BINDING SITE FOR RESIDUE MG A 1338 source : EC2 131) chain A residue 1232 type sequence T description BINDING SITE FOR RESIDUE MG A 1338 source : EC2 132) chain A residue 1112 type sequence F description BINDING SITE FOR RESIDUE MG A 1339 source : EC3 133) chain A residue 1113 type sequence N description BINDING SITE FOR RESIDUE MG A 1339 source : EC3 134) chain A residue 727 type sequence Q description BINDING SITE FOR RESIDUE MG A 1340 source : EC4 135) chain A residue 813 type sequence H description BINDING SITE FOR RESIDUE MG A 1340 source : EC4 136) chain A residue 875 type sequence A description BINDING SITE FOR RESIDUE MG A 1340 source : EC4 137) chain A residue 1226 type sequence F description BINDING SITE FOR RESIDUE MG A 1340 source : EC4 138) chain A residue 1135 type ACT_SITE sequence X description Nucleophile => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI1 139) chain A residue 1260 type ACT_SITE sequence H description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI2 140) chain A residue 1262 type ACT_SITE sequence E description ACT_SITE => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI2 141) chain A residue 307 type BINDING sequence G description BINDING => ECO:0000255|HAMAP-Rule:MF_00419 source Swiss-Prot : SWS_FT_FI3 142) chain A residue 386 type BINDING sequence T description source Swiss-Prot : SWS_FT_FI4 143) chain A residue 678 type BINDING sequence A description source Swiss-Prot : SWS_FT_FI4 144) chain A residue 886 type BINDING sequence S description source Swiss-Prot : SWS_FT_FI4 145) chain A residue 679 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 146) chain A residue 718 type BINDING sequence E description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 147) chain A residue 722 type BINDING sequence N description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5 148) chain A residue 884 type BINDING sequence D description BINDING => ECO:0000255|HAMAP-Rule:MF_00419, ECO:0000269|PubMed:15301531, ECO:0000269|PubMed:22683785, ECO:0000269|PubMed:24223728 source Swiss-Prot : SWS_FT_FI5

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