eF-site ID 4lgd-D PDB Code 4lgd Chain D click to enlarge Title Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 Classification SIGNALING PROTEIN Compound Serine/threonine-protein kinase 3 Source Homo sapiens (Human) (RASF5_HUMAN) Sequence D:  LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESG QVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQ LTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD FTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL ITEAMEIKAKRHEEQQRELEEEELDPMMEREIEELRQRYT AKRQPILDAMDAKKRRQQ Description Functional site 1) chain D residue 35 type sequence E description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 2) chain D residue 36 type sequence G description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 3) chain D residue 37 type sequence S description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 4) chain D residue 39 type sequence G description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 5) chain D residue 41 type sequence V description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 6) chain D residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 7) chain D residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 8) chain D residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 9) chain D residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 10) chain D residue 153 type sequence L description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 11) chain D residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 12) chain D residue 164 type sequence D description BINDING SITE FOR RESIDUE MG D 502 source : BC7 13) chain D residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 14) chain D residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 15) chain D residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 16) chain D residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 17) chain D residue 14 type sequence L description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 18) chain D residue 15 type sequence S description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 19) chain D residue 18 type sequence S description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 20) chain D residue 46 type sequence H description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 21) chain D residue 48 type sequence E description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 22) chain D residue 19 type sequence L description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 23) chain D residue 20 type sequence T description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 24) chain D residue 90 type sequence F description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 25) chain D residue 121 type sequence D description BINDING SITE FOR RESIDUE NA D 506 source : CC2 26) chain D residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 27) chain D residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 28) chain D residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 29) chain D residue 33 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 30) chain D residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 31) chain D residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 32) chain D residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

Display surface Download Links