eF-site ID 4lgd-C PDB Code 4lgd Chain C click to enlarge Title Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 Classification SIGNALING PROTEIN Compound Serine/threonine-protein kinase 3 Source Homo sapiens (Human) (RASF5_HUMAN) Sequence C:  KKLSEDSLTKQPEEVFDVLEKSVFKAIHKESGQVVAIKQV PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV MEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC LVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIK AKRHEEQQRELEEEEFDFLKNLSLEELQMRLKALDPMMER EIEELRQRYTAKRQPILDAMDAKKRRQQN Description Functional site 1) chain C residue 41 type sequence V description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 2) chain C residue 54 type sequence A description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 3) chain C residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 4) chain C residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 5) chain C residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 6) chain C residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 7) chain C residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 8) chain C residue 164 type sequence D description BINDING SITE FOR RESIDUE MG C 502 source : BC2 9) chain C residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 10) chain C residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 11) chain C residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 12) chain C residue 197 type sequence G description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 13) chain C residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 14) chain C residue 121 type sequence D description BINDING SITE FOR RESIDUE NA C 504 source : BC4 15) chain C residue 89 type sequence Y description BINDING SITE FOR RESIDUE NA C 505 source : BC5 16) chain C residue 90 type sequence F description BINDING SITE FOR RESIDUE NA C 505 source : BC5 17) chain C residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 18) chain C residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 19) chain C residue 450 type MOD_RES sequence M description Phosphothreonine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 20) chain C residue 444 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI12 21) chain C residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 22) chain C residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 23) chain C residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 24) chain C residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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