eF-site ID 4lgd-B PDB Code 4lgd Chain B click to enlarge Title Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 Classification SIGNALING PROTEIN Compound Serine/threonine-protein kinase 3 Source Homo sapiens (Human) (RASF5_HUMAN) Sequence B:  KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKES GQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSY FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAG QLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI TSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSD DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRD LITEAMEIKAKRHEEQQRELEEEELSLEELQMRLKALDPM MEREIEELRQRYTAKRQPILDAMDAKKRRQ Description Functional site 1) chain B residue 36 type sequence G description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 2) chain B residue 37 type sequence S description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 3) chain B residue 39 type sequence G description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 4) chain B residue 54 type sequence A description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 5) chain B residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 6) chain B residue 99 type sequence M description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 7) chain B residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 8) chain B residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 9) chain B residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 10) chain B residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 11) chain B residue 164 type sequence D description BINDING SITE FOR RESIDUE MG B 502 source : AC5 12) chain B residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 13) chain B residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 14) chain B residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 15) chain B residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 16) chain B residue 14 type sequence L description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 17) chain B residue 15 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 18) chain B residue 18 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 19) chain B residue 46 type sequence H description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 20) chain B residue 48 type sequence E description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 21) chain B residue 121 type sequence D description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 22) chain B residue 124 type sequence A description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 23) chain B residue 277 type sequence F description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 24) chain B residue 280 type sequence N description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 25) chain B residue 281 type sequence A description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 26) chain B residue 19 type sequence L description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 27) chain B residue 20 type sequence T description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 28) chain B residue 21 type sequence K description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 29) chain B residue 22 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 30) chain B residue 89 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 31) chain B residue 90 type sequence F description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 32) chain B residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 33) chain B residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 34) chain B residue 450 type MOD_RES sequence M description Phosphothreonine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 35) chain B residue 444 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI12 36) chain B residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 33 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 38) chain B residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 39) chain B residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 40) chain B residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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