eF-site ID 4lgd-ABCDEFGH PDB Code 4lgd Chain A, B, C, D, E, F, G, H click to enlarge Title Structural Basis for Autoactivation of Human Mst2 Kinase and Its Regulation by RASSF5 Classification SIGNALING PROTEIN Compound Serine/threonine-protein kinase 3 Source Homo sapiens (Human) (RASF5_HUMAN) Sequence A:  EDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESGQVVAI KQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDL WIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLE YLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTM AKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMA EGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFV KKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAM EIKAKRHEEQQRELEEEEFDFLKNLSLEELQMRLKALDPM MEREIEELRQRYTAKRQPILDAMDAKKRRQ B:  KLKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKES GQVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSY FKNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKS TLKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAG QLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGI TSIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSD DFTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRD LITEAMEIKAKRHEEQQRELEEEELSLEELQMRLKALDPM MEREIEELRQRYTAKRQPILDAMDAKKRRQ C:  KKLSEDSLTKQPEEVFDVLEKSVFKAIHKESGQVVAIKQV PVESDLQEIIKEISIMQQCDSPYVVKYYGSYFKNTDLWIV MEYCGAGSVSDIIRLRNKTLIEDEIATILKSTLKGLEYLH FMRKIHRNIKAGNILLNTEGHAKLADFGVAGQLTDTMAKR NTVIGTPFWMAPEVIQEIGYNCVADIWSLGITSIEMAEGK PPYADIHPMRAIFMIPTNPPPTFRKPELWSDDFTDFVKKC LVKNPEQRATATQLLQHPFIKNAKPVSILRDLITEAMEIK AKRHEEQQRELEEEEFDFLKNLSLEELQMRLKALDPMMER EIEELRQRYTAKRQPILDAMDAKKRRQQN D:  LKKLSEDSLTKQPEEVFDVLEKLGEGSYGSVFKAIHKESG QVVAIKQVPVESDLQEIIKEISIMQQCDSPYVVKYYGSYF KNTDLWIVMEYCGAGSVSDIIRLRNKTLIEDEIATILKST LKGLEYLHFMRKIHRNIKAGNILLNTEGHAKLADFGVAGQ LTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGIT SIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDD FTDFVKKCLVKNPEQRATATQLLQHPFIKNAKPVSILRDL ITEAMEIKAKRHEEQQRELEEEELDPMMEREIEELRQRYT AKRQPILDAMDAKKRRQQ E:  VEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQKL EEALRES F:  DAFSIPELQNFLTILEKEEQDKIQQVQKK G:  EVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQK LEEALRES H:  EVEWDAFSIPELQNFLTILEKEEQDKIQQVQKKYDKFRQK Description Functional site 1) chain A residue 33 type sequence L description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 2) chain A residue 35 type sequence E description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 3) chain A residue 36 type sequence G description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 4) chain A residue 41 type sequence V description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 5) chain A residue 54 type sequence A description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 6) chain A residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 7) chain A residue 99 type sequence M description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 8) chain A residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 9) chain A residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 10) chain A residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 11) chain A residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP A 501 source : AC1 12) chain A residue 164 type sequence D description BINDING SITE FOR RESIDUE MG A 502 source : AC2 13) chain A residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 14) chain A residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 15) chain A residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 16) chain A residue 197 type sequence G description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 17) chain A residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 503 source : AC3 18) chain B residue 36 type sequence G description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 19) chain B residue 37 type sequence S description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 20) chain B residue 39 type sequence G description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 21) chain B residue 54 type sequence A description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 22) chain B residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 23) chain B residue 99 type sequence M description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 24) chain B residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 25) chain B residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 26) chain B residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 27) chain B residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP B 501 source : AC4 28) chain B residue 164 type sequence D description BINDING SITE FOR RESIDUE MG B 502 source : AC5 29) chain B residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 30) chain B residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 31) chain B residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 32) chain B residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 503 source : AC6 33) chain B residue 14 type sequence L description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 34) chain B residue 15 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 35) chain B residue 18 type sequence S description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 36) chain B residue 46 type sequence H description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 37) chain B residue 48 type sequence E description BINDING SITE FOR RESIDUE SO4 B 504 source : AC7 38) chain B residue 121 type sequence D description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 39) chain B residue 124 type sequence A description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 40) chain B residue 277 type sequence F description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 41) chain B residue 280 type sequence N description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 42) chain B residue 281 type sequence A description BINDING SITE FOR RESIDUE SO4 B 505 source : AC8 43) chain B residue 19 type sequence L description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 44) chain B residue 20 type sequence T description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 45) chain B residue 21 type sequence K description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 46) chain B residue 22 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 47) chain B residue 89 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 48) chain B residue 90 type sequence F description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 49) chain E residue 379 type sequence N description BINDING SITE FOR RESIDUE SO4 B 506 source : AC9 50) chain C residue 41 type sequence V description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 51) chain C residue 54 type sequence A description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 52) chain C residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 53) chain C residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 54) chain C residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 55) chain C residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 56) chain C residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP C 501 source : BC1 57) chain C residue 164 type sequence D description BINDING SITE FOR RESIDUE MG C 502 source : BC2 58) chain C residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 59) chain C residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 60) chain C residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 61) chain C residue 197 type sequence G description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 62) chain C residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 C 503 source : BC3 63) chain C residue 121 type sequence D description BINDING SITE FOR RESIDUE NA C 504 source : BC4 64) chain C residue 89 type sequence Y description BINDING SITE FOR RESIDUE NA C 505 source : BC5 65) chain C residue 90 type sequence F description BINDING SITE FOR RESIDUE NA C 505 source : BC5 66) chain H residue 379 type sequence N description BINDING SITE FOR RESIDUE NA C 505 source : BC5 67) chain D residue 35 type sequence E description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 68) chain D residue 36 type sequence G description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 69) chain D residue 37 type sequence S description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 70) chain D residue 39 type sequence G description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 71) chain D residue 41 type sequence V description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 72) chain D residue 56 type sequence K description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 73) chain D residue 100 type sequence E description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 74) chain D residue 102 type sequence C description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 75) chain D residue 109 type sequence D description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 76) chain D residue 153 type sequence L description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 77) chain D residue 164 type sequence D description BINDING SITE FOR RESIDUE ANP D 501 source : BC6 78) chain D residue 164 type sequence D description BINDING SITE FOR RESIDUE MG D 502 source : BC7 79) chain D residue 145 type sequence R description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 80) chain D residue 168 type sequence A description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 81) chain D residue 169 type sequence G description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 82) chain D residue 198 type sequence Y description BINDING SITE FOR RESIDUE SO4 D 503 source : BC8 83) chain D residue 14 type sequence L description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 84) chain D residue 15 type sequence S description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 85) chain D residue 18 type sequence S description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 86) chain D residue 46 type sequence H description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 87) chain D residue 48 type sequence E description BINDING SITE FOR RESIDUE SO4 D 504 source : BC9 88) chain D residue 19 type sequence L description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 89) chain D residue 20 type sequence T description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 90) chain D residue 90 type sequence F description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 91) chain G residue 379 type sequence N description BINDING SITE FOR RESIDUE SO4 D 505 source : CC1 92) chain D residue 121 type sequence D description BINDING SITE FOR RESIDUE NA D 506 source : CC2 93) chain C residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 94) chain C residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 95) chain D residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 96) chain D residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 97) chain A residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 98) chain A residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 99) chain B residue 174 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 100) chain B residue 180 type MOD_RES sequence T description Phosphothreonine; by autocatalysis => ECO:0000269|PubMed:23972470 source Swiss-Prot : SWS_FT_FI7 101) chain A residue 450 type MOD_RES sequence M description Phosphothreonine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 102) chain B residue 450 type MOD_RES sequence M description Phosphothreonine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 103) chain C residue 450 type MOD_RES sequence M description Phosphothreonine => ECO:0007744|PubMed:19369195, ECO:0007744|PubMed:23186163 source Swiss-Prot : SWS_FT_FI9 104) chain C residue 444 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI12 105) chain B residue 444 type MOD_RES sequence S description Phosphoserine => ECO:0007744|PubMed:18691976, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI12 106) chain C residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 107) chain D residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 108) chain A residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 109) chain B residue 146 type ACT_SITE sequence N description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI1 110) chain B residue 33 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 111) chain D residue 33 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 112) chain A residue 33 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 113) chain D residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 114) chain B residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 115) chain C residue 15 type MOD_RES sequence S description Phosphoserine; by PLK1 => ECO:0000269|PubMed:21723128, ECO:0007744|PubMed:19369195 source Swiss-Prot : SWS_FT_FI5 116) chain A residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 117) chain B residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 118) chain C residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 119) chain D residue 117 type MOD_RES sequence T description Phosphothreonine; by PKB/AKT1 => ECO:0000269|PubMed:20086174, ECO:0000269|PubMed:20231902 source Swiss-Prot : SWS_FT_FI6 120) chain A residue 33-56 type prosite sequence LGEGSYGSVFKAIHKESGQVVAIK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGEGSYGSVFkAihkesgqv..........VAIK source prosite : PS00107 121) chain A residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 122) chain B residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 123) chain C residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3 124) chain D residue 56 type BINDING sequence K description source Swiss-Prot : SWS_FT_FI3

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