eF-site ID 4lg0-ABCD
PDB Code 4lg0
Chain A, B, C, D

click to enlarge
Title Structure of a ternary FOXO1-ETS1 DNA complex
Classification TRANSCRIPTION/DNA
Compound Forkhead box protein O1
Source Homo sapiens (Human) (4LG0)
Sequence A:  RRNAWGNLSYADLITKAIESSAEKRLTLSQIYEWMVKSVP
YFKDKGDSNSSAGWKNSIRHNLSLHSKFIRVQNEGTGKSS
WWMLNPEGG
B:  GPIQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVA
RRWGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVY
RFVCDLQSLLGYTPEELHAMLDVKPD
C:  TTCACGGTTTCCTGTTATTGT
D:  AAACAATAACAGGAAACCGTG
Description


Functional site

1) chain A
residue 217
type
sequence L
description BINDING SITE FOR RESIDUE CA A 301
source : AC1

2) chain A
residue 218
type
sequence S
description BINDING SITE FOR RESIDUE CA A 301
source : AC1

3) chain A
residue 220
type
sequence H
description BINDING SITE FOR RESIDUE CA A 301
source : AC1

4) chain A
residue 223
type
sequence F
description BINDING SITE FOR RESIDUE CA A 301
source : AC1

5) chain B
residue 338
type
sequence W
description BINDING SITE FOR RESIDUE PG4 B 501
source : AC2

6) chain B
residue 415
type
sequence V
description BINDING SITE FOR RESIDUE PG4 B 501
source : AC2

7) chain B
residue 416
type
sequence C
description BINDING SITE FOR RESIDUE PG4 B 501
source : AC2

8) chain B
residue 417
type
sequence D
description BINDING SITE FOR RESIDUE PG4 B 501
source : AC2

9) chain A
residue 218
type MOD_RES
sequence S
description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI4

10) chain A
residue 234
type MOD_RES
sequence S
description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI4

11) chain A
residue 235
type MOD_RES
sequence S
description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI4

12) chain A
residue 158
type SITE
sequence N
description DNA-binding => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI2

13) chain A
residue 165
type SITE
sequence Y
description DNA-binding => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI2

14) chain A
residue 225
type SITE
sequence R
description DNA-binding => ECO:0000269|PubMed:18786403
source Swiss-Prot : SWS_FT_FI2

15) chain B
residue 335-415
type DNA_BIND
sequence IQLWQFLLELLTDKSCQSFISWTGDGWEFKLSDPDEVARR
WGKRKNKPKMNYEKLSRGLRYYYDKNIIHKTAGKRYVYRF
V
description ETS => ECO:0000255|PROSITE-ProRule:PRU00237
source Swiss-Prot : SWS_FT_FI1

16) chain A
residue 212
type MOD_RES
sequence S
description Phosphoserine; by STK4/MST1 => ECO:0000269|PubMed:18786403, ECO:0000269|PubMed:19221179, ECO:0000269|PubMed:21245099
source Swiss-Prot : SWS_FT_FI3

17) chain B
residue 337-345
type prosite
sequence LWQFLLELL
description ETS_DOMAIN_1 Ets-domain signature 1. LWQFLLELL
source prosite : PS00345

18) chain B
residue 381-396
type prosite
sequence KPKMNYEKLSRGLRYY
description ETS_DOMAIN_2 Ets-domain signature 2. KpkMnYEkLSRGLRyY
source prosite : PS00346

19) chain A
residue 209-215
type prosite
sequence WKNSIRH
description FORK_HEAD_2 Fork head domain signature 2. WKNSIRH
source prosite : PS00658


Display surface

Download
Links