eF-site ID 4l7e-AB PDB Code 4l7e Chain A, B click to enlarge Title Three dimensional structure of mutant D78A of human HD domain-containing protein 2, Genomics Consortium (NESG) Target HR6723 Classification SIGNALING PROTEIN Compound HD domain-containing protein 2 Source Homo sapiens (Human) (HDDC2_HUMAN) Sequence A:  HGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESVSDHXY RXAVXAXVIKDDRLNKDRCVRLALVHAXAECIVGDIAPAD NIPKEEKHRREEEAXKQITQLLPEDLRKELYELWEEYETQ SSAEAKFVKQLDQCEXILQASEYEDLEHKPGRLQDFYDST AGKFNHPEIVQLVSELEAERSTNIAAA B:  ATFXGHGARSLLQFLRLVGQLKRVPRTGWVYRNVQRPESV SDHXYRXAVXAXVIKDDRLNKDRCVRLALVHAXAECIVGD IAPADNIPKEEKHRREEEAXKQITQLLPEDLRKELYELWE EYETQSSAEAKFVKQLDQCEXILQASEYEDLEHKPGRLQD FYDSTAGKFNHPEIVQLVSELEAERSTNIAAA Description Functional site 1) chain A residue 32 type sequence R description BINDING SITE FOR RESIDUE CL A 301 source : AC1 2) chain A residue 49 type sequence H description BINDING SITE FOR RESIDUE CL A 301 source : AC1 3) chain A residue 77 type sequence H description BINDING SITE FOR RESIDUE CL A 301 source : AC1 4) chain A residue 143 type sequence D description BINDING SITE FOR RESIDUE CL A 301 source : AC1 5) chain A residue 173 type sequence G description BINDING SITE FOR RESIDUE PEG A 302 source : AC2 6) chain A residue 176 type sequence N description BINDING SITE FOR RESIDUE PEG A 302 source : AC2 7) chain A residue 132 type sequence S description BINDING SITE FOR RESIDUE PEG A 303 source : AC3 8) chain A residue 137 type sequence K description BINDING SITE FOR RESIDUE PEG A 303 source : AC3 9) chain A residue 41 type sequence Q description BINDING SITE FOR RESIDUE PEG A 304 source : AC4 10) chain A residue 158 type sequence E description BINDING SITE FOR RESIDUE PEG A 304 source : AC4 11) chain A residue 160 type sequence K description BINDING SITE FOR RESIDUE PEG A 304 source : AC4 12) chain A residue 163 type sequence R description BINDING SITE FOR RESIDUE PEG A 304 source : AC4 13) chain A residue 82 type sequence C description BINDING SITE FOR RESIDUE PEG A 305 source : AC5 14) chain A residue 83 type sequence I description BINDING SITE FOR RESIDUE PEG A 305 source : AC5 15) chain A residue 85 type sequence G description BINDING SITE FOR RESIDUE PEG A 305 source : AC5 16) chain B residue 32 type sequence R description BINDING SITE FOR RESIDUE CL B 301 source : AC6 17) chain B residue 49 type sequence H description BINDING SITE FOR RESIDUE CL B 301 source : AC6 18) chain B residue 77 type sequence H description BINDING SITE FOR RESIDUE CL B 301 source : AC6 19) chain B residue 143 type sequence D description BINDING SITE FOR RESIDUE CL B 301 source : AC6 20) chain A residue 166 type sequence D description BINDING SITE FOR RESIDUE PEG B 302 source : AC7 21) chain B residue 39 type sequence N description BINDING SITE FOR RESIDUE PEG B 302 source : AC7 22) chain B residue 160 type sequence K description BINDING SITE FOR RESIDUE PEG B 302 source : AC7 23) chain B residue 163 type sequence R description BINDING SITE FOR RESIDUE PEG B 302 source : AC7 24) chain B residue 26 type sequence Q description BINDING SITE FOR RESIDUE PEG B 303 source : AC8 25) chain B residue 29 type sequence R description BINDING SITE FOR RESIDUE PEG B 303 source : AC8 26) chain B residue 30 type sequence V description BINDING SITE FOR RESIDUE PEG B 303 source : AC8 27) chain B residue 82 type sequence C description BINDING SITE FOR RESIDUE PEG B 303 source : AC8 28) chain B residue 83 type sequence I description BINDING SITE FOR RESIDUE PEG B 303 source : AC8 29) chain B residue 173 type sequence G description BINDING SITE FOR RESIDUE PEG B 305 source : AC9 30) chain B residue 176 type sequence N description BINDING SITE FOR RESIDUE PEG B 305 source : AC9 31) chain A residue 90 type sequence A description BINDING SITE FOR RESIDUE PEG B 306 source : BC1 32) chain A residue 92 type sequence N description BINDING SITE FOR RESIDUE PEG B 306 source : BC1 33) chain B residue 36 type sequence V description BINDING SITE FOR RESIDUE PEG B 306 source : BC1 34) chain B residue 40 type sequence V description BINDING SITE FOR RESIDUE PEG B 306 source : BC1 35) chain A residue 49 type BINDING sequence H description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 36) chain A residue 77 type BINDING sequence H description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 37) chain A residue 78 type BINDING sequence A description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 38) chain A residue 143 type BINDING sequence D description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 39) chain B residue 49 type BINDING sequence H description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 40) chain B residue 77 type BINDING sequence H description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 41) chain B residue 78 type BINDING sequence A description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 42) chain B residue 143 type BINDING sequence D description BINDING => ECO:0007744|PDB:4DMB source Swiss-Prot : SWS_FT_FI1 43) chain A residue 81 type BINDING sequence E description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2 44) chain A residue 86 type BINDING sequence D description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2 45) chain A residue 87 type BINDING sequence I description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2 46) chain B residue 81 type BINDING sequence E description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2 47) chain B residue 86 type BINDING sequence D description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2 48) chain B residue 87 type BINDING sequence I description BINDING => ECO:0007744|PDB:4L7W source Swiss-Prot : SWS_FT_FI2

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