eF-site ID 4l42-A PDB Code 4l42 Chain A click to enlarge Title Crystal structures of human p70S6K1-PIF Classification TRANSFERASE Compound RPS6KB1 protein Source (Q7Z721_HUMAN) Sequence A:  EKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMK VLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQ TGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEIS MALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKES IHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALM YDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDL LKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLAR KVEPPFKEMFRDFEYIADW Description Functional site 1) chain A residue 75 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 2) chain A residue 76 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 3) chain A residue 77 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 4) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 5) chain A residue 80 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 6) chain A residue 81 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 7) chain A residue 100 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 8) chain A residue 102 type sequence L description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 9) chain A residue 149 type sequence L description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 10) chain A residue 150 type sequence E description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 11) chain A residue 151 type sequence Y description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 12) chain A residue 152 type sequence L description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 13) chain A residue 217 type sequence C description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 14) chain A residue 218 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 15) chain A residue 248 type sequence N description BINDING SITE FOR RESIDUE SO4 A 402 source : AC2 16) chain A residue 249 type sequence R description BINDING SITE FOR RESIDUE SO4 A 402 source : AC2 17) chain A residue 232 type sequence G description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 18) chain A residue 233 type sequence T description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 19) chain A residue 234 type sequence I description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 20) chain A residue 235 type sequence E description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 21) chain A residue 275 type sequence R description BINDING SITE FOR RESIDUE SO4 A 403 source : AC3 22) chain A residue 274 type sequence N description BINDING SITE FOR RESIDUE SO4 A 404 source : AC4 23) chain A residue 275 type sequence R description BINDING SITE FOR RESIDUE SO4 A 404 source : AC4 24) chain A residue 72 type sequence R description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 25) chain A residue 84 type sequence Q description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 26) chain A residue 151 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 27) chain A residue 189 type sequence K description BINDING SITE FOR RESIDUE SO4 A 405 source : AC5 28) chain A residue 112 type sequence K description BINDING SITE FOR RESIDUE SO4 A 406 source : AC6 29) chain A residue 227 type sequence T description BINDING SITE FOR RESIDUE SO4 A 406 source : AC6 30) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE SO4 A 406 source : AC6 31) chain A residue 229 type sequence T description BINDING SITE FOR RESIDUE SO4 A 406 source : AC6 32) chain A residue 244 type sequence R description BINDING SITE FOR RESIDUE SO4 A 406 source : AC6 33) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE SO4 A 407 source : AC7 34) chain A residue 113 type sequence D description BINDING SITE FOR RESIDUE SO4 A 407 source : AC7 35) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE SO4 A 407 source : AC7 36) chain A residue 276 type sequence K description BINDING SITE FOR RESIDUE SO4 A 407 source : AC7 37) chain A residue 306 type sequence K description BINDING SITE FOR RESIDUE SO4 A 408 source : AC8 38) chain A residue 307 type sequence R description BINDING SITE FOR RESIDUE SO4 A 408 source : AC8 39) chain A residue 308 type sequence N description BINDING SITE FOR RESIDUE SO4 A 408 source : AC8 40) chain A residue 217 type sequence C description BINDING SITE FOR RESIDUE ZN A 409 source : AC9 41) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN A 409 source : AC9 42) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE ZN A 409 source : AC9 43) chain A residue 231 type sequence C description BINDING SITE FOR RESIDUE ZN A 409 source : AC9 44) chain A residue 195 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 45) chain A residue 74 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 46) chain A residue 100 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 47) chain A residue 389 type MOD_RES sequence E description Phosphothreonine; by MTOR, NEK6 and NEK7 => ECO:0000269|PubMed:29236692, ECO:0000269|PubMed:29750193 source Swiss-Prot : SWS_FT_FI5 48) chain A residue 74-100 type prosite sequence LGKGGYGKVFQVRKVTGANTGKIFAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGYGKVFqVrkvtgantgki.......FAMK source prosite : PS00107 49) chain A residue 191-203 type prosite sequence IIYRDLKPENIML description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNIML source prosite : PS00108 50) chain A residue 229 type MOD_RES sequence T description Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:19864428, ECO:0000269|PubMed:9445476 source Swiss-Prot : SWS_FT_FI3

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