eF-site ID 4l3j-A PDB Code 4l3j Chain A click to enlarge Title Crystal structures of human p70S6K1 kinase domain Classification TRANSFERASE Compound RPS6KB1 protein Source (Q7Z721_HUMAN) Sequence A:  KIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKV LKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQT GGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISM ALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI HDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMY DMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLL KKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARK VEPPFKPLLQS Description Functional site 1) chain A residue 75 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 2) chain A residue 77 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 3) chain A residue 79 type sequence Y description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 4) chain A residue 80 type sequence G description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 5) chain A residue 81 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 6) chain A residue 82 type sequence V description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 7) chain A residue 98 type sequence A description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 8) chain A residue 102 type sequence L description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 9) chain A residue 150 type sequence E description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 10) chain A residue 152 type sequence L description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 11) chain A residue 202 type sequence M description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 12) chain A residue 218 type sequence K description BINDING SITE FOR RESIDUE 5FI A 401 source : AC1 13) chain A residue 217 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 14) chain A residue 222 type sequence H description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 15) chain A residue 228 type sequence H description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 16) chain A residue 231 type sequence C description BINDING SITE FOR RESIDUE ZN A 402 source : AC2 17) chain A residue 195 type ACT_SITE sequence D description Proton acceptor => ECO:0000255|PROSITE-ProRule:PRU00159, ECO:0000255|PROSITE-ProRule:PRU10027 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 74 type BINDING sequence L description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 19) chain A residue 100 type BINDING sequence K description BINDING => ECO:0000255|PROSITE-ProRule:PRU00159 source Swiss-Prot : SWS_FT_FI2 20) chain A residue 229 type MOD_RES sequence T description Phosphothreonine; by PDPK1 => ECO:0000269|PubMed:19864428, ECO:0000269|PubMed:9445476 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 74-100 type prosite sequence LGKGGYGKVFQVRKVTGANTGKIFAMK description PROTEIN_KINASE_ATP Protein kinases ATP-binding region signature. LGKGGYGKVFqVrkvtgantgki.......FAMK source prosite : PS00107 22) chain A residue 191-203 type prosite sequence IIYRDLKPENIML description PROTEIN_KINASE_ST Serine/Threonine protein kinases active-site signature. IiYrDLKpeNIML source prosite : PS00108

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