|
eF-site ID
|
4kts-A |
PDB Code
|
4kts |
Chain
|
A |
|
click to enlarge
|
|
Title
|
Bovine trypsin in complex with microviridin J at pH 8.5 |
Classification
|
HYDROLASE/HYDROLASE INHIBITOR |
Compound
|
Cationic trypsin |
Source
|
ORGANISM_COMMON: bovine,cow,domestic cattle,domestic cow; ORGANISM_SCIENTIFIC: Bos taurus; |
|
Sequence
|
A: |
IVGGYTCGANTVPYQVSLNSGYHFCGGSLINSQWVVSAAH
CYKSGIQVRLGEDNINVVEGNEQFISASKSIVHPSYNSNT
LNNDIMLIKLKSAASLNSRVASISLPTSCASAGTQCLISG
WGNTKSSGTSYPDVLKCLKAPILSDSSCKSAYPGQITSNM
FCAGYLEGGKDSCQGDSGGPVVCSGKLQGIVSWGSGCAQK
NKPGVYTKVCNYVSWIKQTIASN
|
|
Description
|
|
Functional site
|
|
1)
|
chain |
A |
residue |
70 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE CA A 301
|
source |
: AC1
|
|
2)
|
chain |
A |
residue |
72 |
type |
|
sequence |
N
|
description |
BINDING SITE FOR RESIDUE CA A 301
|
source |
: AC1
|
|
3)
|
chain |
A |
residue |
75 |
type |
|
sequence |
V
|
description |
BINDING SITE FOR RESIDUE CA A 301
|
source |
: AC1
|
|
4)
|
chain |
A |
residue |
80 |
type |
|
sequence |
E
|
description |
BINDING SITE FOR RESIDUE CA A 301
|
source |
: AC1
|
|
5)
|
chain |
A |
residue |
96 |
type |
|
sequence |
S
|
description |
BINDING SITE FOR RESIDUE PEG B 101
|
source |
: AC2
|
|
6)
|
chain |
A |
residue |
70 |
type |
BINDING |
sequence |
E
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
7)
|
chain |
A |
residue |
72 |
type |
BINDING |
sequence |
N
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
8)
|
chain |
A |
residue |
75 |
type |
BINDING |
sequence |
V
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
9)
|
chain |
A |
residue |
80 |
type |
BINDING |
sequence |
E
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
10)
|
chain |
A |
residue |
189 |
type |
BINDING |
sequence |
D
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
11)
|
chain |
A |
residue |
192 |
type |
BINDING |
sequence |
Q
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
12)
|
chain |
A |
residue |
195 |
type |
BINDING |
sequence |
S
|
description |
|
source |
Swiss-Prot : SWS_FT_FI2
|
|
13)
|
chain |
A |
residue |
57 |
type |
ACT_SITE |
sequence |
H
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
14)
|
chain |
A |
residue |
102 |
type |
ACT_SITE |
sequence |
D
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
15)
|
chain |
A |
residue |
195 |
type |
ACT_SITE |
sequence |
S
|
description |
Charge relay system
|
source |
Swiss-Prot : SWS_FT_FI1
|
|
16)
|
chain |
A |
residue |
53-58 |
type |
prosite |
sequence |
VSAAHC
|
description |
TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. VSAAHC
|
source |
prosite : PS00134
|
|
17)
|
chain |
A |
residue |
189-200 |
type |
prosite |
sequence |
DSCQGDSGGPVV
|
description |
TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPVV
|
source |
prosite : PS00135
|
|
|
|