eF-site ID 4ksd-AB PDB Code 4ksd Chain A, B click to enlarge Title Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Classification MEMBRANE PROTEIN, TRANSPORT PROTEIN Compound Multidrug resistance protein 1A Source (4KSD) Sequence A:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE HGTHQQLLAQKGIYFSMVSVQA B:  QVQLQESGGGLVQAGGSLRLSCAASGRTFNSAVMGWFRQA PGKERQFVATIDWSGEYTYYADSVKGRFTISRDNAKNTVY LQMTSLKPEDTALYYCAARLTLGQFDYWGQGTQVTVSS Description (1)  Multidrug resistance protein 1A (E.C.3.6.3.44), R2 protein Functional site 1) chain A residue 44-66 type TRANSMEM sequence WLDRLYMLVGTLAAIIHGVALPL description Helical source Swiss-Prot : SWS_FT_FI2 2) chain A residue 851-870 type TRANSMEM sequence WQLTLLLLAIVPIIAIAGVV description Helical source Swiss-Prot : SWS_FT_FI2 3) chain A residue 931-953 type TRANSMEM sequence AHVFGITFSFTQAMMYFSYAACF description Helical source Swiss-Prot : SWS_FT_FI2 4) chain A residue 970-991 type TRANSMEM sequence VLLVFSAIVFGAMAVGQVSSFA description Helical source Swiss-Prot : SWS_FT_FI2 5) chain A residue 113-133 type TRANSMEM sequence YYTGIGAGVLIVAYIQVSFWC description Helical source Swiss-Prot : SWS_FT_FI2 6) chain A residue 183-204 type TRANSMEM sequence GDKIGMFFQAMATFFGGFIIGF description Helical source Swiss-Prot : SWS_FT_FI2 7) chain A residue 212-232 type TRANSMEM sequence LVILAISPVLGLSAGIWAKIL description Helical source Swiss-Prot : SWS_FT_FI2 8) chain A residue 291-312 type TRANSMEM sequence ANISMGAAFLLIYASYALAFWY description Helical source Swiss-Prot : SWS_FT_FI2 9) chain A residue 327-348 type TRANSMEM sequence VLTVFFSVLIGAFSVGQASPNI description Helical source Swiss-Prot : SWS_FT_FI2 10) chain A residue 708-728 type TRANSMEM sequence VVGIFCAIINGGLQPAFSVIF description Helical source Swiss-Prot : SWS_FT_FI2 11) chain A residue 753-773 type TRANSMEM sequence LLFLILGIISFITFFLQGFTF description Helical source Swiss-Prot : SWS_FT_FI2 12) chain A residue 829-849 type TRANSMEM sequence LAVIFQNIANLGTGIIISLIY description Helical source Swiss-Prot : SWS_FT_FI2 13) chain A residue 134-182 type TOPO_DOM sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD DVSKINEGI description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 14) chain A residue 233-290 type TOPO_DOM sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAIT description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 15) chain A residue 349-707 type TOPO_DOM sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD EDVPPASFWRILKLNSTEWPYF description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 16) chain A residue 774-828 type TOPO_DOM sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR LANDAAQVKGATGSR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 17) chain A residue 871-930 type TOPO_DOM sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ KFETMYAQSLQIPYRNAMKK description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 67-112 type TOPO_DOM sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE MTTYAY description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 19) chain A residue 205-211 type TOPO_DOM sequence TRGWKLT description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 20) chain A residue 313-326 type TOPO_DOM sequence GTSLVISKEYSIGQ description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 21) chain A residue 729-752 type TOPO_DOM sequence SKVVGVFTNGGPPETQRQNSNLFS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 22) chain A residue 850 type TOPO_DOM sequence G description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 23) chain A residue 954-969 type TOPO_DOM sequence RFGAYLVTQQLMTFEN description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 24) chain A residue 423 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 25) chain A residue 1066 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 83 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 87 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 28) chain A residue 90 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 29) chain A residue 527-541 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 30) chain A residue 1172-1186 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211

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