eF-site ID 4ksb-A PDB Code 4ksb Chain A click to enlarge Title Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain Classification MEMBRANE PROTEIN, TRANSPORT PROTEIN Compound Multidrug resistance protein 1A Source (MDR1A_MOUSE) Sequence A:  VSVLTMFRYAGWLDRLYMLVGTLAAIIHGVALPLMMLIFG DMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEEMTTYAY YYTGIGAGVLIVAYIQVSFWCLAAGRQIHKIRQKFFHAIM NQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQA MATFFGGFIIGFTRGWKLTLVILAISPVLGLSAGIWAKIL SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAITANISMGAAFLLIYASYALAFWY GTSLVISKEYSIGQVLTVFFSVLIGAFSVGQASPNIEAFA NARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNLEFKN IHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCGKSTT VQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGVVSQE PVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDFIMKL PHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDE ATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTVRNAD VIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLDEDVP PASFWRILKLNSTEWPYFVVGIFCAIINGGLQPAFSVIFS KVVGVFTNGGPPETQRQNSNLFSLLFLILGIISFITFFLQ GFTFGKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGA LTTRLANDAAQVKGATGSRLAVIFQNIANLGTGIIISLIY GWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGS GKIATEAIENFRTVVSLTREQKFETMYAQSLQIPYRNAMK KAHVFGITFSFTQAMMYFSYAACFRFGAYLVTQQLMTFEN VLLVFSAIVFGAMAVGQVSSFAPDYAKATVSASHIIRIIE KTPEIDSYSTQGLKPNMLEGNVQFSGVVFNYPTRPSIPVL QGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPMAGS VFLDGKEIKQLNVQWLRAQLGIVSQEPILFDCSIAENIAY GDNSRVVSYEEIVRAAKEANIHQFIDSLPDKYNTRVGDKG TQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKV VQEALDKAREGRTCIVIAHRLSTIQNADLIVVIQNGKVKE HGTHQQLLAQKGIYFSMVSVQA Description Functional site 1) chain A residue 1066 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 2) chain A residue 423 type BINDING sequence G description BINDING => ECO:0000255|PROSITE-ProRule:PRU00434 source Swiss-Prot : SWS_FT_FI4 3) chain A residue 87 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 4) chain A residue 90 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 5) chain A residue 83 type CARBOHYD sequence N description N-linked (GlcNAc...) asparagine => ECO:0000255 source Swiss-Prot : SWS_FT_FI6 6) chain A residue 134-182 type TOPO_DOM sequence LAAGRQIHKIRQKFFHAIMNQEIGWFDVHDVGELNTRLTD DVSKINEGI description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 7) chain A residue 233-290 type TOPO_DOM sequence SSFTDKELHAYAKAGAVAEEVLAAIRTVIAFGGQKKELER YNNNLEEAKRLGIKKAIT description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 8) chain A residue 349-707 type TOPO_DOM sequence EAFANARGAAYEVFKIIDNKPSIDSFSKSGHKPDNIQGNL EFKNIHFSYPSRKEVQILKGLNLKVKSGQTVALVGNSGCG KSTTVQLMQRLYDPLDGMVSIDGQDIRTINVRYLREIIGV VSQEPVLFATTIAENIRYGREDVTMDEIEKAVKEANAYDF IMKLPHQFDTLVGERGAQLSGGQKQRIAIARALVRNPKIL LLDEATSALDTESEAVVQAALDKAREGRTTIVIAHRLSTV RNADVIAGFDGGVIVEQGNHDELMREKGIYFKLVMTQTLD EDVPPASFWRILKLNSTEWPYF description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 9) chain A residue 774-828 type TOPO_DOM sequence GKAGEILTKRLRYMVFKSMLRQDVSWFDDPKNTTGALTTR LANDAAQVKGATGSR description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 10) chain A residue 871-930 type TOPO_DOM sequence EMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTREQ KFETMYAQSLQIPYRNAMKK description Cytoplasmic => ECO:0000250 source Swiss-Prot : SWS_FT_FI1 11) chain A residue 67-112 type TOPO_DOM sequence MMLIFGDMTDSFASVGNVSKNSTNMSEADKRAMFAKLEEE MTTYAY description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 12) chain A residue 205-211 type TOPO_DOM sequence TRGWKLT description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 13) chain A residue 313-326 type TOPO_DOM sequence GTSLVISKEYSIGQ description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 14) chain A residue 729-752 type TOPO_DOM sequence SKVVGVFTNGGPPETQRQNSNLFS description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 15) chain A residue 954-969 type TOPO_DOM sequence RFGAYLVTQQLMTFEN description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 16) chain A residue 850 type TOPO_DOM sequence G description Extracellular => ECO:0000250 source Swiss-Prot : SWS_FT_FI3 17) chain A residue 527-541 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 18) chain A residue 1172-1186 type prosite sequence LSGGQKQRIAIARAL description ABC_TRANSPORTER_1 ABC transporters family signature. LSGGQKQRIAIARAL source prosite : PS00211 19) chain A residue 44-66 type TRANSMEM sequence WLDRLYMLVGTLAAIIHGVALPL description Helical source Swiss-Prot : SWS_FT_FI2 20) chain A residue 113-133 type TRANSMEM sequence YYTGIGAGVLIVAYIQVSFWC description Helical source Swiss-Prot : SWS_FT_FI2 21) chain A residue 183-204 type TRANSMEM sequence GDKIGMFFQAMATFFGGFIIGF description Helical source Swiss-Prot : SWS_FT_FI2 22) chain A residue 212-232 type TRANSMEM sequence LVILAISPVLGLSAGIWAKIL description Helical source Swiss-Prot : SWS_FT_FI2 23) chain A residue 291-312 type TRANSMEM sequence ANISMGAAFLLIYASYALAFWY description Helical source Swiss-Prot : SWS_FT_FI2 24) chain A residue 327-348 type TRANSMEM sequence VLTVFFSVLIGAFSVGQASPNI description Helical source Swiss-Prot : SWS_FT_FI2 25) chain A residue 708-728 type TRANSMEM sequence VVGIFCAIINGGLQPAFSVIF description Helical source Swiss-Prot : SWS_FT_FI2 26) chain A residue 753-773 type TRANSMEM sequence LLFLILGIISFITFFLQGFTF description Helical source Swiss-Prot : SWS_FT_FI2 27) chain A residue 829-849 type TRANSMEM sequence LAVIFQNIANLGTGIIISLIY description Helical source Swiss-Prot : SWS_FT_FI2 28) chain A residue 851-870 type TRANSMEM sequence WQLTLLLLAIVPIIAIAGVV description Helical source Swiss-Prot : SWS_FT_FI2 29) chain A residue 931-953 type TRANSMEM sequence AHVFGITFSFTQAMMYFSYAACF description Helical source Swiss-Prot : SWS_FT_FI2 30) chain A residue 970-991 type TRANSMEM sequence VLLVFSAIVFGAMAVGQVSSFA description Helical source Swiss-Prot : SWS_FT_FI2

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