eF-site ID 4kn7-X PDB Code 4kn7 Chain X click to enlarge Title X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c Classification TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source Escherichia coli (strain K12) (RPOD_ECOLI) Sequence X:  QSQLKLLVTRGKEQGYLTYAEVNDHLPEDIVDSDQIEDII QMINDMGIQVMEEAPDADDTDPVRMYMREMGTVELLTREG EIDIAKRIEDGINQVQCSVAEYPEAITYLLEQYDRVEAEI DPELAREKFAELRAQYVVTRDTIKAKGRSHATAQEEILKL SEVFKQFRLVPKQFDYLVNSMRVMMDRVRTQERLIMKLCV EQCKMPKKNFITLFTGNETSDTWFNAAIAMNKPWSEKLHD VSEEVHRALQKLQQIEEETGLTIEQVKDINRRMSIGEAKA RRAKKEMVEANLRLVISIAKKYTNRGLQFLDLIQEGNIGL MKAVDKFEYRRGYKFSTYATWWIRQAITRSIADQARTIRI PVHMIETINKLNRISRQMLQEMGREPTPEELAERMLMPED KIRKVLKIAKEPISMETPIGDDEDSHLGDFIEDTTLELPL DSATTESLRAATHDVLAGLTAREAKVLRMRFGIDMNTDYT LEEVGKQFDVTRERIRQIEAKALRKLRHPSRSEVLRS Description Functional site 1) chain X residue 513 type sequence D description BINDING SITE FOR RESIDUE 1RM C 1401 source : AC1 2) chain X residue 514 type sequence D description BINDING SITE FOR RESIDUE 1RM C 1401 source : AC1 3) chain X residue 515 type sequence E description BINDING SITE FOR RESIDUE 1RM C 1401 source : AC1 4) chain X residue 573-592 type DNA_BIND sequence LEEVGKQFDVTRERIRQIEA description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 5) chain X residue 562 type SITE sequence R description Interaction with anti-sigma factors source Swiss-Prot : SWS_FT_FI2 6) chain X residue 403-416 type prosite sequence DLIQEGNIGLMKAV description SIGMA70_1 Sigma-70 factors family signature 1. DLIQeGnIGLMkAV source prosite : PS00715 7) chain X residue 572-598 type prosite sequence TLEEVGKQFDVTRERIRQIEAKALRKL description SIGMA70_2 Sigma-70 factors family signature 2. TleEVGkqfdVTrerIrQIEakaLrkL source prosite : PS00716

Display surface Download Links