eF-site ID 4kn7-I PDB Code 4kn7 Chain I click to enlarge Title X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c Classification TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source Escherichia coli (strain K12) (RPOD_ECOLI) Sequence I:  LKAQTKTEEFDAIKIALASPDMIRSWSFGEVKKPETINYR TFKPERDGLFCARIFGPVKDYECLCGKYKRLKHRGVICEK CGVEVTQTKVRRERMGHIELASPTAHIWFLKSLPSRIGLL LDMPLRDIERVLYFESYVVIEGGMTNLERQQILTEEQYLD ALEEFGDEFDAKMGAEAIQALLKSMDLEQECEQLREELNE TNSETKRKKLTKRIKLLEAFVQSGNKPEWMILTVLPVLPP DLRPLVPLDGGRFATSDLNDLYRRVINRNNRLKRLLDLAA PDIIVRNEKRMLQEAVDALLDNGRRGRAITGSNKRPLKSL ADMIKGGKRVDYSGRSVITVGPYLRLHQCGLPKKMALELF KPFIYGKLELRGLATTIKAAKKMVEREEAVVWDILDEVIR EHPVLLNRAPTLHRLGIQAFEPVLIEGKAIQLHPLVCAAY NADFDGDQMAVHVPLTLEAQLEARALMMSTNNILSPANGE PIIVPSQDVVLGLYYMTRDCVNAKGEGMVLTGPKEAERLY RSGLASLHARVKVRITEYEKDANGELVAKTSLKDTTVGRA ILWMIVPKGLPYSIVNQALGKKAISKMLNTCYRILGLKPT VIFADQIMYTGFAYAARSGASVGIDDMVIPEKKHEIISEA EAEVAEIQEQFQSGLVTAGERYNKVIDIWAAANDRVSKAM MDNLQTETVINRDGQEEKQVSFNSIYMMADSGARGSAAQI RQLAGMRGLMAKPDGSIIETPITANFREGLNVLQYFISTH GARKGLADTALKTANSGYLTRRLVDVAQDLVVTEDDCGTH EGIMMTPVIEGGDVKEPLRDRVLGRVTAEDVLKPGTADIL VPRNTLLHEQWCDLLEENSVDAVKVRSVVSCDTDFGVCAH CYGRDLARGHIINKGEAIGVIAAQSIGEPGTQLTMRDITG GLPRVADLFEARRPKEPAILAEISGIVSFGKETKGKRRLV ITPVDGSDPYEEMIPKWRQLNVFEGERVERGDVISDGPEA PHDILRLRGVHAVTRYIVNEVQDVYRLQGVKINDKHIEVI VRQMLRKATIVNAGSSDFLEGEQVEYSRVKIANRELEANG KVGATYSRDLLGITKASLATESFISAASFQETTRVLTEAA VAGKRDELRGLKENVIVGRLIPAGTGYAYHQDRMRRRAAG Description Functional site 1) chain I residue 70 type sequence C description BINDING SITE FOR RESIDUE ZN I 1501 source : AC6 2) chain I residue 72 type sequence C description BINDING SITE FOR RESIDUE ZN I 1501 source : AC6 3) chain I residue 85 type sequence C description BINDING SITE FOR RESIDUE ZN I 1501 source : AC6 4) chain I residue 88 type sequence C description BINDING SITE FOR RESIDUE ZN I 1501 source : AC6 5) chain I residue 814 type sequence C description BINDING SITE FOR RESIDUE ZN I 1502 source : AC7 6) chain I residue 888 type sequence C description BINDING SITE FOR RESIDUE ZN I 1502 source : AC7 7) chain I residue 895 type sequence C description BINDING SITE FOR RESIDUE ZN I 1502 source : AC7 8) chain I residue 898 type sequence C description BINDING SITE FOR RESIDUE ZN I 1502 source : AC7 9) chain I residue 462 type sequence D description BINDING SITE FOR RESIDUE MG I 1503 source : AC8 10) chain I residue 464 type sequence D description BINDING SITE FOR RESIDUE MG I 1503 source : AC8 11) chain I residue 70 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 12) chain I residue 72 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 13) chain I residue 85 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 14) chain I residue 88 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 15) chain I residue 460 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 16) chain I residue 462 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 17) chain I residue 464 type DNA_BIND sequence D description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 18) chain I residue 814 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 19) chain I residue 888 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 20) chain I residue 895 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1 21) chain I residue 898 type DNA_BIND sequence C description H-T-H motif => ECO:0000255|HAMAP-Rule:MF_00963 source Swiss-Prot : SWS_FT_FI1

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