eF-site ID 4kn7-H PDB Code 4kn7 Chain H click to enlarge Title X-ray crystal structure of the Escherichia coli RNA polymerase in complex with Benzoxazinorifamycin-2c Classification TRANSFERASE/ANTIBIOTIC Compound DNA-directed RNA polymerase subunit alpha Source Escherichia coli (strain K12) (RPOD_ECOLI) Sequence H:  KKRIRKDFGKRPQVLDVPYLLSIQLDSFQKFIEQDPEGQY GLEAAFRSVFPIQSYSGNSELQYVSYRLGEPVFDVQECQI RGVTYSAPLRVKLRLVIYEREAPEGTVKDIKEQEVYMGEI PLMTDNGTFVINGTERVIVSQLHRSPGVFFDSDKGKTHSS GKVLYNARIIPYRGSWLDFEFDPKDNLFVRIDRRRKLPAT IILRALNYTTEQILDLFFEKVIFEIRDNKLQMELVPERLR GETASFDIEANGKVYVEKGRRITARHIRQLEKDDVKLIEV PVEYIAGKVVAKDYIDESTGELICAANMELSLDLLAKLSQ SGHKRIETLFTNDLDHGPYISETLRVDPTNDRLSALVEIY RMMRPGEPPTREAAESLFENLFFSEDRYDLSAVGRMKFNR SLLREEIEGSGILSKDDIIDVMKKLIDIRNGKGEVDDIDH LGNRRIRSVGEMAENQFRVGLVRVERAVKERLSLGDLDTL MPQDMINAKPISAAVKEFFGSSQLSQFMDQNNPLSEITHK RRISALGPGGLTRERAGFEVRDVHPTHYGRVCPIETPEGP NIGLINSLSVYAQTNEYGFLETPYRKVTDGVVTDEIHYLS AIEEGNYVIAQANSNLDEEGHFVEDLVTCRSKGESSLFSR DQVDYMDVSTQQVVSVGASLIPFLEHDDANRALMGANMQR QAVPTLRADKPLVGTGMERAVAVDSGVTAVAKRGGVVQYV DASRIVIKVNEDEMYPGEAGIDIYNLTKYTRSNQNTCINQ MPCVSLGEPVERGDVLADGPSTDLGELALGQNMRVAFMPW NGYNFEDSILVSERVVQEDRFTTIHIQELACVSRDTKLGP EEITADIPNVGEAALSKLDESGIVYIGAEVTGGDILVGKV TPKGETQLTPEEKLLRAIFGEKASDVKDSSLRVPNGVSGT VIDVQVFTRDGVEKDKRALEIEEMQLKQAKKDLSEELQIL EAGLFSRIRAVLVAGGVEAEKLDKLPRDRWLELGLTDEEK QNQLEQLAEQYDELKHEFEKKLEAKRRKITQGDDLAPGVL KIVKVYLAVKRRIQPGDKMAGRHGNKGVISKINPIEDMPY DENGTPVDIVLNPLGVPSRMNIGQILETHLGMAAKGIGDK INAMLKQQQEVAKLREFIQRAYDLGADVRQKVDLSTFSDE EVMRLAENLRKGMPIATPVFDGAKEAEIKELLKLGDLPTS GQIRLYDGRTGEQFERPVTVGYMYMLKLNHLVDDKMHARS TGSYSLVTQQPLGGKAQFGGQRFGEMEVWALEAYGAAYTL QEMLTVKSDDVNGRTKMYKNIVDGNHQMEPGMPESFNVLL KEIRSLGINIELEDE Description Functional site 1) chain H residue 509 type sequence S description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 2) chain H residue 510 type sequence Q description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 3) chain H residue 513 type sequence Q description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 4) chain H residue 514 type sequence F description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 5) chain H residue 516 type sequence D description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 6) chain H residue 526 type sequence H description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 7) chain H residue 529 type sequence R description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 8) chain H residue 531 type sequence S description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 9) chain H residue 533 type sequence L description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 10) chain H residue 568 type sequence N description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 11) chain H residue 572 type sequence I description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5 12) chain H residue 687 type sequence R description BINDING SITE FOR RESIDUE 1RM H 1401 source : AC5

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