eF-site ID 4kjk-A PDB Code 4kjk Chain A click to enlarge Title Room Temperature WT DHFR Classification OXIDOREDUCTASE Compound Dihydrofolate reductase Source (DYR_ECOLI) Sequence A:  MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPV IMGRHTWESIGRPLPGRKNIILSSQPGTDDRVTWVKSVDE AIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR Description Functional site 1) chain A residue 5 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 2) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 3) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 4) chain A residue 20 type sequence M description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 5) chain A residue 27 type sequence D description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 6) chain A residue 28 type sequence L description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 7) chain A residue 29 type sequence A description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 8) chain A residue 31 type sequence F description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 9) chain A residue 32 type sequence K description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 10) chain A residue 50 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 11) chain A residue 52 type sequence R description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 12) chain A residue 57 type sequence R description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 13) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 14) chain A residue 113 type sequence T description BINDING SITE FOR RESIDUE FOL A 201 source : AC1 15) chain A residue 116 type sequence D description BINDING SITE FOR RESIDUE CA A 202 source : AC2 16) chain A residue 149 type sequence H description BINDING SITE FOR RESIDUE CA A 202 source : AC2 17) chain A residue 159 type sequence R description BINDING SITE FOR RESIDUE CA A 202 source : AC2 18) chain A residue 10 type sequence V description BINDING SITE FOR RESIDUE CA A 203 source : AC3 19) chain A residue 13 type sequence V description BINDING SITE FOR RESIDUE CA A 203 source : AC3 20) chain A residue 119 type sequence V description BINDING SITE FOR RESIDUE CA A 203 source : AC3 21) chain A residue 6 type sequence A description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 22) chain A residue 7 type sequence A description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 23) chain A residue 14 type sequence I description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 24) chain A residue 15 type sequence G description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 25) chain A residue 18 type sequence N description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 26) chain A residue 19 type sequence A description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 27) chain A residue 20 type sequence M description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 28) chain A residue 22 type sequence W description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 29) chain A residue 43 type sequence G description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 30) chain A residue 44 type sequence R description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 31) chain A residue 45 type sequence H description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 32) chain A residue 46 type sequence T description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 33) chain A residue 49 type sequence S description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 34) chain A residue 62 type sequence L description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 35) chain A residue 63 type sequence S description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 36) chain A residue 64 type sequence S description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 37) chain A residue 65 type sequence Q description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 38) chain A residue 76 type sequence K description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 39) chain A residue 78 type sequence V description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 40) chain A residue 94 type sequence I description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 41) chain A residue 96 type sequence G description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 42) chain A residue 97 type sequence G description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 43) chain A residue 98 type sequence R description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 44) chain A residue 99 type sequence V description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 45) chain A residue 100 type sequence Y description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 46) chain A residue 102 type sequence Q description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 47) chain A residue 123 type sequence T description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 48) chain A residue 131 type sequence D description BINDING SITE FOR RESIDUE NAP A 204 source : AC4 49) chain A residue 113 type BINDING sequence T description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 50) chain A residue 57 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 51) chain A residue 5 type BINDING sequence I description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 52) chain A residue 27 type BINDING sequence D description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 53) chain A residue 52 type BINDING sequence R description BINDING => ECO:0000305|PubMed:9012674 source Swiss-Prot : SWS_FT_FI1 54) chain A residue 13 type BINDING sequence V description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 55) chain A residue 45 type BINDING sequence H description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 56) chain A residue 63 type BINDING sequence S description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 57) chain A residue 76 type BINDING sequence K description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 58) chain A residue 95 type BINDING sequence G description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 59) chain A residue 7 type BINDING sequence A description BINDING => ECO:0000269|PubMed:19374017 source Swiss-Prot : SWS_FT_FI2 60) chain A residue 13-35 type prosite sequence VIGMENAMPWNLPADLAWFKRNT description DHFR_1 Dihydrofolate reductase (DHFR) domain signature. VIGmenaMPWnlpa.DlawFkrnT source prosite : PS00075

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