eF-site ID 4khr-B PDB Code 4khr Chain B click to enlarge Title HCV NS5B GT1A C316Y with GSK5852 Classification REPLICATION/REPLICATION INHIBITOR Compound NS5B RNA-dependent RNA polymerase Source Hepatitis C virus subtype 1a (B1PPP0_9HEPC) Sequence B:  SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYST TSRSACQRQKKVTFDRLQVLDSHYQDVLKEVKAAASKVKA NLLSVEEACSLTPPHSAKSKYGYGAKDVRSHASRAVAHIN SVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQR VEFLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIY QCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCR ASGVLTTSCGNTLTCYIKARAACRAAGLQDCTMLVYGDDL VVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLE QALDCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPG EINRVAACLRKLGVPPLRAWRHRARSVRARLLSRGGRAAI CGKYLFNWAVRTKLKLTPIAAAGQLALSGWFTAGYSGGDI YH Description Functional site 1) chain B residue 209 type sequence K description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 2) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 3) chain B residue 382 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 4) chain B residue 359 type sequence D description BINDING SITE FOR RESIDUE SO4 B 602 source : AC6 5) chain B residue 516 type sequence G description BINDING SITE FOR RESIDUE SO4 B 603 source : AC7 6) chain B residue 517 type sequence R description BINDING SITE FOR RESIDUE SO4 B 603 source : AC7 7) chain B residue 24 type sequence N description BINDING SITE FOR RESIDUE SO4 B 604 source : AC8 8) chain B residue 26 type sequence L description BINDING SITE FOR RESIDUE SO4 B 604 source : AC8 9) chain B residue 436 type sequence R description BINDING SITE FOR RESIDUE SO4 B 604 source : AC8 10) chain B residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 B 605 source : AC9 11) chain B residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 B 605 source : AC9 12) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE SO4 B 605 source : AC9 13) chain B residue 223 type sequence C description BINDING SITE FOR RESIDUE SO4 B 605 source : AC9 14) chain B residue 96 type sequence S description BINDING SITE FOR RESIDUE SO4 B 606 source : BC1 15) chain B residue 97 type sequence A description BINDING SITE FOR RESIDUE SO4 B 606 source : BC1 16) chain B residue 168 type sequence R description BINDING SITE FOR RESIDUE SO4 B 606 source : BC1 17) chain B residue 559 type sequence D description BINDING SITE FOR RESIDUE SO4 B 606 source : BC1 18) chain B residue 505 type sequence R description BINDING SITE FOR RESIDUE SO4 B 607 source : BC2 19) chain B residue 531 type sequence R description BINDING SITE FOR RESIDUE SO4 B 607 source : BC2 20) chain B residue 532 type sequence T description BINDING SITE FOR RESIDUE SO4 B 607 source : BC2

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