eF-site ID 4khr-A PDB Code 4khr Chain A click to enlarge Title HCV NS5B GT1A C316Y with GSK5852 Classification REPLICATION/REPLICATION INHIBITOR Compound NS5B RNA-dependent RNA polymerase Source Hepatitis C virus subtype 1a (B1PPP0_9HEPC) Sequence A:  SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYST TSRSACQRQKKVTFDRLQVLDSHYQDVLKEVKAAASKVKA NLLSVEEACSLTPPHSAKSKYGYGAKDVRSHASRAVAHIN SVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQR VEFLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIY QCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCR ASGVLTTSCGNTLTCYIKARAACRAAGLQDCTMLVYGDDL VVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLE QALDCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPG EINRVAACLRKLGVPPLRAWRHRARSVRARLLSRGGRAAI CGKYLFNWAVRTKLKLTPIAAAGQLALSGWFTAGYSGGDI YH Description Functional site 1) chain A residue 505 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC1 2) chain A residue 530 type sequence V description BINDING SITE FOR RESIDUE SO4 A 601 source : AC1 3) chain A residue 531 type sequence R description BINDING SITE FOR RESIDUE SO4 A 601 source : AC1 4) chain A residue 532 type sequence T description BINDING SITE FOR RESIDUE SO4 A 601 source : AC1 5) chain A residue 516 type sequence G description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 6) chain A residue 517 type sequence R description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 7) chain A residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 8) chain A residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 9) chain A residue 221 type sequence T description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 10) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 11) chain A residue 223 type sequence C description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 12) chain A residue 197 type sequence P description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 13) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 14) chain A residue 204 type sequence L description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 15) chain A residue 314 type sequence L description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 16) chain A residue 316 type sequence Y description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 17) chain A residue 319 type sequence D description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 18) chain A residue 321 type sequence V description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 19) chain A residue 363 type sequence I description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 20) chain A residue 365 type sequence S description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 21) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 22) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 23) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 24) chain A residue 415 type sequence F description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 25) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1PV A 604 source : AC4 26) chain A residue 24 type sequence N description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 27) chain A residue 26 type sequence L description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 28) chain A residue 436 type sequence R description BINDING SITE FOR RESIDUE SO4 B 601 source : AC5 29) chain A residue 437 type sequence D description BINDING SITE FOR RESIDUE SO4 B 602 source : AC6 30) chain A residue 438 type sequence Q description BINDING SITE FOR RESIDUE SO4 B 602 source : AC6 31) chain A residue 439 type sequence L description BINDING SITE FOR RESIDUE SO4 B 602 source : AC6 32) chain A residue 514 type sequence R description BINDING SITE FOR RESIDUE SO4 B 602 source : AC6

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