eF-site ID 4khm-B PDB Code 4khm Chain B click to enlarge Title HCV NS5B GT1A with GSK5852 Classification REPLICATION/REPLICATION INHIBITOR Compound HCV Polymerase Source Hepatitis C virus subtype 1a (B1PPP0_9HEPC) Sequence B:  SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYST TSRSACQRQKKVTFDRLQVLDSHYQDVLKEVKAAASKVKA NLLSVEEACSLTPPHSAKSKYGYGAKDVRSHASRAVAHIN SVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQR VEFLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIY QCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCR ASGVLTTSCGNTLTCYIKARAACRAAGLQDCTMLVCGDDL VVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLE QALDCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPG EINRVAACLRKLGVPPLRAWRHRARSVRARLLSRGGRAAI CGKYLFNWAVRTKLKLTPIAAAGQLALSGWFTAGYSGGDI YH Description Functional site 1) chain B residue 193 type sequence F description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 2) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 3) chain B residue 204 type sequence L description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 4) chain B residue 314 type sequence L description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 5) chain B residue 316 type sequence C description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 6) chain B residue 319 type sequence D description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 7) chain B residue 321 type sequence V description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 8) chain B residue 363 type sequence I description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 9) chain B residue 365 type sequence S description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 10) chain B residue 366 type sequence C description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 11) chain B residue 368 type sequence S description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 12) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 13) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1PV B 601 source : AC4 14) chain B residue 209 type sequence K description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5 15) chain B residue 380 type sequence R description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5 16) chain B residue 382 type sequence Y description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5 17) chain B residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 B 603 source : AC6 18) chain B residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 B 603 source : AC6 19) chain B residue 222 type sequence R description BINDING SITE FOR RESIDUE SO4 B 603 source : AC6 20) chain B residue 223 type sequence C description BINDING SITE FOR RESIDUE SO4 B 603 source : AC6 21) chain B residue 24 type sequence N description BINDING SITE FOR RESIDUE SO4 B 604 source : AC7 22) chain B residue 26 type sequence L description BINDING SITE FOR RESIDUE SO4 B 604 source : AC7 23) chain B residue 436 type sequence R description BINDING SITE FOR RESIDUE SO4 B 604 source : AC7 24) chain B residue 516 type sequence G description BINDING SITE FOR RESIDUE SO4 B 605 source : AC8 25) chain B residue 517 type sequence R description BINDING SITE FOR RESIDUE SO4 B 605 source : AC8 26) chain B residue 505 type sequence R description BINDING SITE FOR RESIDUE SO4 B 606 source : AC9 27) chain B residue 531 type sequence R description BINDING SITE FOR RESIDUE SO4 B 606 source : AC9 28) chain B residue 532 type sequence T description BINDING SITE FOR RESIDUE SO4 B 606 source : AC9

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