eF-site ID 4khm-A PDB Code 4khm Chain A click to enlarge Title HCV NS5B GT1A with GSK5852 Classification REPLICATION/REPLICATION INHIBITOR Compound HCV Polymerase Source Hepatitis C virus subtype 1a (B1PPP0_9HEPC) Sequence A:  SMSYSWTGALVTPCAAEEQKLPINALSNSLLRHHNLVYST TSRSACQRQKKVTFDRLQVLDSHYQDVLKEVKAAASKVKA NLLSVEEACSLTPPHSAKSKYGYGAKDVRSHASRAVAHIN SVWKDLLEDSVTPIDTTIMAKNEVFCVQPEKGGRKPARLI VFPDLGVRVCEKMALYDVVSKLPLAVMGSSYGFQYSPGQR VEFLVQAWKSKKTPMGFSYDTRCFDSTVTESDIRTEEAIY QCCDLDPQARVAIKSLTERLYVGGPLTNSRGENCGYRRCR ASGVLTTSCGNTLTCYIKARAACRAAGLQDCTMLVCGDDL VVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDL ELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETA RHTPVNSWLGNIIMFAPTLWARMILMTHFFSVLIARDQLE QALDCEIYGACYSIEPLDLPPIIQRLHGLSAFSLHSYSPG EINRVAACLRKLGVPPLRAWRHRARSVRARLLSRGGRAAI CGKYLFNWAVRTKLKLTPIAAAGQLALSGWFTAGYSGGDI YH Description Functional site 1) chain A residue 193 type sequence F description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 2) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 3) chain A residue 204 type sequence L description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 4) chain A residue 314 type sequence L description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 5) chain A residue 316 type sequence C description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 6) chain A residue 363 type sequence I description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 7) chain A residue 365 type sequence S description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 8) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 9) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 10) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 11) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1PV A 601 source : AC1 12) chain A residue 505 type sequence R description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 13) chain A residue 531 type sequence R description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 14) chain A residue 532 type sequence T description BINDING SITE FOR RESIDUE SO4 A 602 source : AC2 15) chain A residue 48 type sequence R description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 16) chain A residue 51 type sequence K description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 17) chain A residue 222 type sequence R description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 18) chain A residue 223 type sequence C description BINDING SITE FOR RESIDUE SO4 A 603 source : AC3 19) chain A residue 24 type sequence N description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5 20) chain A residue 26 type sequence L description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5 21) chain A residue 436 type sequence R description BINDING SITE FOR RESIDUE SO4 B 602 source : AC5

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