|
|
eF-site ID
|
4kcu-B |
|
PDB Code
|
4kcu |
|
Chain
|
B |
|
click to enlarge
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Title
|
Pyruvate kinase (PYK) from Trypanosoma brucei soaked with D-Malate |
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Classification
|
TRANSFERASE |
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Compound
|
Pyruvate kinase 1 |
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Source
|
Trypanosoma brucei brucei (KPYK1_TRYBB) |
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Sequence
|
B: |
SQLEHNIGLSIFEPVAKHRANRIVCTIGPSTQSVEALKNL
MKSGMSVARMNFSHGSHEYHQTTINNVRAAAAELGLHIGI
ALDTKGPEIRTGLFKDGEVSFAPGDIVCVTTDPAYEKVGT
KEKFYIDYPQLTNAVRPGGSIYVDDGVMTLRVVSKEDDRT
LKCHVNNHHRLTDRRGINLPGCEVDLPAVSEKDRKDLEFG
VAQGVDMIFASFIRTAEQVREVRAALGEKGKDILIISKIE
NHQGVQNIDSIIEASNGIMVARGDLGVEIPAEKVCVAQMC
IISKCNVVGKPVICATQMLESMTSNPRPTRAEVSDVANAV
LNGADCVMLSGETAKGKYPNEVVQYMARICVEAQSATHDT
VMFNSIKNLQKIPMCPEEAVCSSAVASAFEVQAKAMLVLS
NTGRSARLISKYRPNCPIICVTTRLQTCRQLNVTRSVVSV
FYDAAKSGEDKDKEKRVKLGLDFAKKEKYASTGDVVVVVH
ADHSVKGYPNQTRLIYLP
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Description
|
|
Functional site
|
|
|
1)
|
chain |
B |
| residue |
52 |
| type |
BINDING |
| sequence |
N
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
2)
|
chain |
B |
| residue |
54 |
| type |
BINDING |
| sequence |
S
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
3)
|
chain |
B |
| residue |
84 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
4)
|
chain |
B |
| residue |
85 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
5)
|
chain |
B |
| residue |
264 |
| type |
BINDING |
| sequence |
G
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
6)
|
chain |
B |
| residue |
265 |
| type |
BINDING |
| sequence |
D
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
7)
|
chain |
B |
| residue |
297 |
| type |
BINDING |
| sequence |
T
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
8)
|
chain |
B |
| residue |
50 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI1
|
|
|
9)
|
chain |
B |
| residue |
91 |
| type |
BINDING |
| sequence |
R
|
| description |
BINDING => ECO:0000250|UniProtKB:P14618
|
| source |
Swiss-Prot : SWS_FT_FI2
|
|
|
10)
|
chain |
B |
| residue |
241 |
| type |
BINDING |
| sequence |
E
|
| description |
BINDING => ECO:0000255
|
| source |
Swiss-Prot : SWS_FT_FI3
|
|
|
11)
|
chain |
B |
| residue |
239 |
| type |
SITE |
| sequence |
K
|
| description |
Transition state stabilizer => ECO:0000250
|
| source |
Swiss-Prot : SWS_FT_FI4
|
|
|
|