eF-site ID 4kbi-AB PDB Code 4kbi Chain A, B click to enlarge Title HCV NS5B GT1B N316Y with CMPD 4 Classification REPLICATION/REPLICATION INHIBITOR Compound HCV Polymerase Source Hepatitis C virus genotype 1b (isolate BK) (HCV) (POLG_HCVBK) Sequence A:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSAGQRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKYGYGAKDVRNLSSRAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVYGDDLVVICE SAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTKLKLTPIPYSGGDIYHS B:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSAGQRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKYGYGAKDVRNLSSRAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQPRKPARLIVFPD LGVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFL VNTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCD LAPEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGV LTTSCGNTLTCYLKASAACRAAKLQDCTMLVYGDDLVVIC ESAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELIT SCSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTP VNSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALD CQIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINR VASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKY LFNWAVKTKLKLTPIPGYSGGDIYH Description Functional site 1) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 2) chain A residue 204 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 3) chain A residue 314 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 4) chain A residue 316 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 5) chain A residue 321 type sequence V description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 6) chain A residue 363 type sequence I description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 7) chain A residue 365 type sequence S description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 8) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 9) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 10) chain A residue 384 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 11) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 12) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 13) chain A residue 447 type sequence I description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 14) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 15) chain B residue 200 type sequence R description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 16) chain B residue 204 type sequence L description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 17) chain B residue 314 type sequence L description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 18) chain B residue 316 type sequence Y description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 19) chain B residue 319 type sequence D description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 20) chain B residue 321 type sequence V description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 21) chain B residue 363 type sequence I description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 22) chain B residue 365 type sequence S description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 23) chain B residue 368 type sequence S description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 24) chain B residue 384 type sequence L description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 25) chain B residue 414 type sequence M description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 26) chain B residue 415 type sequence Y description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 27) chain B residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1C0 B 601 source : AC2 28) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 29) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 30) chain B residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 31) chain B residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 32) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 33) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 34) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 35) chain B residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 36) chain B residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 37) chain B residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1

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