eF-site ID 4kbi-A PDB Code 4kbi Chain A click to enlarge Title HCV NS5B GT1B N316Y with CMPD 4 Classification REPLICATION/REPLICATION INHIBITOR Compound HCV Polymerase Source Hepatitis C virus genotype 1b (isolate BK) (HCV) (POLG_HCVBK) Sequence A:  SMSYTWTGALITPCAAEESKLPINALSNSLLRHHNMVYAT TSRSAGQRQKKVTFDRLQVLDDHYRDVLKEMKAKASTVKA KLLSVEEACKLTPPHSAKSKYGYGAKDVRNLSSRAVNHIH SVWKDLLEDTVTPIDTTIMAKNEVFCVQRKPARLIVFPDL GVRVCEKMALYDVVSTLPQVVMGSSYGFQYSPGQRVEFLV NTWKSKKNPMGFSYDTRCFDSTVTENDIRVEESIYQCCDL APEARQAIKSLTERLYIGGPLTNSKGQNCGYRRCRASGVL TTSCGNTLTCYLKASAACRAAKLQDCTMLVYGDDLVVICE SAGTQEDAASLRVFTEAMTRYSAPPGDPPQPEYDLELITS CSSNVSVAHDASGKRVYYLTRDPTTPLARAAWETARHTPV NSWLGNIIMYAPTLWARMILMTHFFSILLAQEQLEKALDC QIYGACYSIEPLDLPQIIERLHGLSAFSLHSYSPGEINRV ASCLRKLGVPPLRVWRHRARSVRARLLSQGGRAATCGKYL FNWAVKTKLKLTPIPYSGGDIYHS Description Functional site 1) chain A residue 200 type sequence R description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 2) chain A residue 204 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 3) chain A residue 314 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 4) chain A residue 316 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 5) chain A residue 321 type sequence V description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 6) chain A residue 363 type sequence I description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 7) chain A residue 365 type sequence S description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 8) chain A residue 366 type sequence C description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 9) chain A residue 368 type sequence S description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 10) chain A residue 384 type sequence L description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 11) chain A residue 414 type sequence M description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 12) chain A residue 415 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 13) chain A residue 447 type sequence I description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 14) chain A residue 448 type sequence Y description BINDING SITE FOR RESIDUE 1C0 A 601 source : AC1 15) chain A residue 29 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 16) chain A residue 42 type MOD_RES sequence S description Phosphoserine; by host => ECO:0000250|UniProtKB:P26662 source Swiss-Prot : SWS_FT_FI2 17) chain A residue 220 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 18) chain A residue 318 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1 19) chain A residue 319 type BINDING sequence D description BINDING => ECO:0000305|PubMed:10557268, ECO:0000305|PubMed:11884572 source Swiss-Prot : SWS_FT_FI1

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