eF-site ID 4k7u-B PDB Code 4k7u Chain B click to enlarge Title Crystal structure of Zn2.3-hUb (human ubiquitin) adduct from a solution 70 mM zinc acetate/1.3 mM hUb Classification LIGASE Compound ubiquitin Source Homo sapiens (Human) (UBC_HUMAN) Sequence B:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR Description Functional site 1) chain B residue 51 type sequence E description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 2) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 103 source : AC3 3) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 104 source : AC4 4) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE EDO A 106 source : AC6 5) chain B residue 15 type sequence L description BINDING SITE FOR RESIDUE EDO A 107 source : AC7 6) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE EDO A 107 source : AC7 7) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE EDO A 107 source : AC7 8) chain B residue 6 type sequence K description BINDING SITE FOR RESIDUE ZN B 101 source : AC9 9) chain B residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN B 101 source : AC9 10) chain B residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN B 102 source : BC1 11) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN B 102 source : BC1 12) chain B residue 6 type sequence K description BINDING SITE FOR RESIDUE ACT B 104 source : BC3 13) chain B residue 68 type sequence H description BINDING SITE FOR RESIDUE ACT B 104 source : BC3 14) chain B residue 48 type sequence K description BINDING SITE FOR RESIDUE EDO B 105 source : BC4 15) chain B residue 49 type sequence Q description BINDING SITE FOR RESIDUE EDO B 105 source : BC4 16) chain B residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN C 102 source : BC6 17) chain B residue 16 type sequence E description BINDING SITE FOR RESIDUE ACT C 103 source : BC7 18) chain B residue 18 type sequence E description BINDING SITE FOR RESIDUE ACT C 103 source : BC7 19) chain B residue 21 type sequence D description BINDING SITE FOR RESIDUE ACT C 103 source : BC7 20) chain B residue 29 type sequence K description BINDING SITE FOR RESIDUE ACT C 103 source : BC7 21) chain B residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 22) chain B residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 23) chain B residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 24) chain B residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 25) chain B residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 26) chain B residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 27) chain B residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 28) chain B residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 29) chain B residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 30) chain B residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 31) chain B residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 32) chain B residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9

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