eF-site ID 4k7u-A PDB Code 4k7u Chain A click to enlarge Title Crystal structure of Zn2.3-hUb (human ubiquitin) adduct from a solution 70 mM zinc acetate/1.3 mM hUb Classification LIGASE Compound ubiquitin Source Homo sapiens (Human) (UBC_HUMAN) Sequence A:  MQIFVKTLTGKTITLEVEPSDTIENVKAKIQDKEGIPPDQ QRLIFAGKQLEDGRTLSDYNIQKESTLHLVLR Description Functional site 1) chain A residue 1 type sequence M description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 2) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE ZN A 101 source : AC1 3) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 102 source : AC2 4) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE ZN A 103 source : AC3 5) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE ZN A 104 source : AC4 6) chain A residue 14 type sequence T description BINDING SITE FOR RESIDUE ACT A 105 source : AC5 7) chain A residue 33 type sequence K description BINDING SITE FOR RESIDUE ACT A 105 source : AC5 8) chain A residue 16 type sequence E description BINDING SITE FOR RESIDUE EDO A 106 source : AC6 9) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE EDO A 106 source : AC6 10) chain A residue 21 type sequence D description BINDING SITE FOR RESIDUE EDO A 106 source : AC6 11) chain A residue 29 type sequence K description BINDING SITE FOR RESIDUE EDO A 106 source : AC6 12) chain A residue 58 type sequence D description BINDING SITE FOR RESIDUE EDO A 107 source : AC7 13) chain A residue 37 type sequence P description BINDING SITE FOR RESIDUE PEG A 108 source : AC8 14) chain A residue 39 type sequence D description BINDING SITE FOR RESIDUE PEG A 108 source : AC8 15) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE ZN B 101 source : AC9 16) chain A residue 32 type sequence D description BINDING SITE FOR RESIDUE ZN B 103 source : BC2 17) chain A residue 6 type sequence K description BINDING SITE FOR RESIDUE ACT B 104 source : BC3 18) chain A residue 66 type sequence T description BINDING SITE FOR RESIDUE ACT B 104 source : BC3 19) chain A residue 68 type sequence H description BINDING SITE FOR RESIDUE ACT B 104 source : BC3 20) chain A residue 63 type sequence K description BINDING SITE FOR RESIDUE EDO B 105 source : BC4 21) chain A residue 51 type sequence E description BINDING SITE FOR RESIDUE ZN C 101 source : BC5 22) chain A residue 18 type sequence E description BINDING SITE FOR RESIDUE EDO C 104 source : BC8 23) chain A residue 63 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:18719106 source Swiss-Prot : SWS_FT_FI12 24) chain A residue 29 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16543144, ECO:0000269|PubMed:25752573, ECO:0000269|PubMed:25752577, ECO:0000269|PubMed:34239127 source Swiss-Prot : SWS_FT_FI10 25) chain A residue 66 type MOD_RES sequence T description (Microbial infection) ADP-ribosylthreonine => ECO:0000269|PubMed:32330457 source Swiss-Prot : SWS_FT_FI4 26) chain A residue 6 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603 source Swiss-Prot : SWS_FT_FI6 27) chain A residue 11 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 28) chain A residue 48 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:16443603, ECO:0000269|PubMed:16543144 source Swiss-Prot : SWS_FT_FI8 29) chain A residue 65 type MOD_RES sequence S description Phosphoserine; by PINK1 => ECO:0000269|PubMed:24660806, ECO:0000269|PubMed:24751536, ECO:0000269|PubMed:24784582, ECO:0000269|PubMed:25527291 source Swiss-Prot : SWS_FT_FI3 30) chain A residue 54 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 31) chain A residue 72 type SITE sequence R description Interacts with activating enzyme source Swiss-Prot : SWS_FT_FI1 32) chain A residue 68 type SITE sequence H description Essential for function source Swiss-Prot : SWS_FT_FI2 33) chain A residue 33 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000269|PubMed:25752577 source Swiss-Prot : SWS_FT_FI11 34) chain A residue 27 type CROSSLNK sequence K description Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) => ECO:0000305|PubMed:15466860 source Swiss-Prot : SWS_FT_FI9 35) chain A residue 27-52 type prosite sequence KAKIQDKEGIPPDQQRLIFAGKQLED description UBIQUITIN_1 Ubiquitin domain signature. KakIqDkegIPpdqQrLIFaGkqleD source prosite : PS00299

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